Synthesis and antimicrobial activity of amine linked bis- and tris-heterocycles

Prakash, T. Bhanu; Reddy, Guda Dinneswara; Padmaja, A.; Padmavathi, V.

doi:10.1016/j.ejmech.2014.06.001

Cited by 29 publications

(19 citation statements)

References 19 publications

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“…A series of pyrazole derivatives linked thiazole and imidazole were prepared and tested for antimicrobial activity. The compounds 188 and 189 exhibited excellent antibacterial and antifungal activities [ 93 ]. Du et al synthesized a series of novel 3-(difluoromethyl)-1-methyl-1 H -pyrazole-4-carboxylic acid amides and tested in vitro for their activities against seven phytopathogenic fungi.…”

Section: Pharmacological Activitiesmentioning

confidence: 99%

Synthesis and Pharmacological Activities of Pyrazole Derivatives: A Review

et al. 2018

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Pyrazole and its derivatives are considered a pharmacologically important active scaffold that possesses almost all types of pharmacological activities. The presence of this nucleus in pharmacological agents of diverse therapeutic categories such as celecoxib, a potent anti-inflammatory, the antipsychotic CDPPB, the anti-obesity drug rimonabant, difenamizole, an analgesic, betazole, a H2-receptor agonist and the antidepressant agent fezolamide have proved the pharmacological potential of the pyrazole moiety. Owing to this diversity in the biological field, this nucleus has attracted the attention of many researchers to study its skeleton chemically and biologically. This review highlights the different synthesis methods and the pharmacological properties of pyrazole derivatives. Studies on the synthesis and biological activity of pyrazole derivatives developed by many scientists around the globe are reported.

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Section: Pharmacological Activitiesmentioning

confidence: 99%

Synthesis and Pharmacological Activities of Pyrazole Derivatives: A Review

et al. 2018

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“…[2] Thus, it is vital requirement to identify novel chemotherapeutic molecules for the cancer treatment. Many heterocyclic molecules were synthesized because of their wide range of biological activities, [3][4][5][6][7][8] for example pyrimidine itself is a member of important of all diazineanalogs in cytosine of DNA and RNA, [9] uracil, [10] thymine [11] and also in purines, [12] uric acid [13] and barbituric acid. [14] So, in the studies of designing and discovery of new pharmacologically and physiologically potential compounds, these gained much notice.…”

Section: Introductionmentioning

confidence: 99%

Synthesis and Anticancer Activity of Some New 2‐Benzyloxy‐5‐alkyne Substituted Pyrimidines: An Application to Sonogashira Coupling

et al. 2020

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Sonogashira coupling between diversely substituted 2‐benzyloxy‐5‐bromopyrimidines and various aryl and aliphatic alkynes in the presence of catalytic amount of PdCl2(PPh3)2 with diethylamine and CuI as a co catalyst in THF at 60 °C afforded 17 new 2‐benzyloxy‐5‐alkyne substituted pyrimidines in good yields (85–94 %). The cytotoxic activity of resulted compounds were evaluated against A549 (Human lung adenocarcinoma cell line), HepG2 (Human liver cancer cell line) and HCT116 (Human colon cancer cell line) cancer cell lines. Some of the 2‐benzyloxy‐5‐alkyne pyrimidines synthesized were found to be shown moderate in vitro cytotoxic activity against A549 cell line.

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“…). In fact, for the last couple of years, we have involved in the synthesis of biologically potential heterocycles adopting facile synthetic methodologies . Ultrasound irradiation is one of the powerful techniques for the promotion of organic reactions, wherein shorter reaction times and higher yields are the unique advantages under this method when compared with conventional methods which required longer reaction times .…”

Section: Introductionmentioning

confidence: 99%

Synthesis of Benzazolyl Pyrimidines Under Ultrasonication and Their Antimicrobial Activity

Kayathi

Sowmya

Padmaja

et al. 2018

Journal of Heterocyclic Chem

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in Wiley Online Library (wileyonlinelibrary.com).(1) The benzoxazolyl/benzothiazolyl/benzimidazolyl pyrimidines were prepared under ultrasonication in the presence of pyridine/dimethylaminopyridine and triethylamine. (2) Better yields were recorded in 4-(N,N-dimethylamino)pyridine and Et 3 N. (3) The presence of electron withdrawing chloro, bromo, and nitro substituents enhanced antimicrobial activity (13c, 13e, 14e: minimum inhibitory concentration = 6.25 μg/well against Bacillus subtilis; 13e, 14e: minimum inhibitory concentration = 6.25 μg/well against Aspergillus niger).

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Synthesis and antimicrobial activity of amine linked bis- and tris-heterocycles

Cited by 29 publications

References 19 publications

Synthesis and Pharmacological Activities of Pyrazole Derivatives: A Review

Synthesis and Pharmacological Activities of Pyrazole Derivatives: A Review

Synthesis and Anticancer Activity of Some New 2‐Benzyloxy‐5‐alkyne Substituted Pyrimidines: An Application to Sonogashira Coupling

Synthesis of Benzazolyl Pyrimidines Under Ultrasonication and Their Antimicrobial Activity

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