Synthesis and antimicrobial activity of novel fluorine containing 4-(substituted-2-hydroxybenzoyl)-1H-pyrazoles and pyrazolyl benzo[d]oxazoles

Gadakh, Amol V.; Pandit, Chetan; Rindhe, Sahebrao S.; Karale, B. K.

doi:10.1016/j.bmcl.2010.07.019

Cited by 40 publications

(9 citation statements)

References 22 publications

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“…Furthermore, a simple super hydrophobic coating composed of nano-structured fluorinated silica colloids with fluoroalkoxysilane on a silane structure demonstrated that the adhesion of Staphylococcus aureus and Pseudomonas aeruginosa was reduced by 2.08 ± 0.25 and 1.76 ± 0.12 log over controls, respectively [20]. The fluorine containing 4-(substituted-2-hydroxybenzoyl) pyrazoles 6, 7, 8 showed promising antibacterial activity [21]. Based on the discoveries that fluorine substituted β-nitrostyrene enhanced antimicrobial activity, this investigation was undertaken to study the effects on antimicrobial activity of difluoro-, trifluoromethyl-and trifluoromethoxy-substituted β-methyl-β-nitrostyrenes and related compounds that were prepared via the Henry reaction [22].…”

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confidence: 99%

A Study of Fluorinated β-Nitrostyrenes as Antimicrobial Agents

Cornell

Nicoletti

et al. 2012

Applied Sciences

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Abstract:The effect of variously fluorine-substituted β-methyl-β-nitrostyrenes on their antimicrobial activity was investigated. Their efficacy was determined by minimum inhibition concentration (MIC) in cultures of Gram positive and Gram negative bacteria and a fungus. Highest activity against the Gram negative bacterium, E.coli, was achieved with 4-fluorine-aryl substituted β-methyl-β-nitrostyrenes, while most compounds gave excellent results against gram positive bacteria. Importantly, the addition of the β-methyl group profoundly enhanced the antibacterial activity of the compounds tested. The comparative K D values for the most potent compounds against E.coli were much lower than those required for the gram positive and fungus counterparts. This investigation illustrated that fluorine substituted nitropropenylarenes have enhanced antimicrobial activity suitable for antibiotic applications.

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confidence: 99%

A Study of Fluorinated β-Nitrostyrenes as Antimicrobial Agents

Cornell

Nicoletti

et al. 2012

Applied Sciences

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“…Several ureid derivatives have also proved to be anti-tumor agents [5], and to inhibit HIV protease and glycine transporter GlyT-2 [6]. However, most urea derivatives were synthesized and studied for their herbicidal activity.…”

Section: Introductionmentioning

confidence: 99%

Facile synthesis and biological evaluation of novel fluorine-containing N-nitro-N′-substituted phenylurea

et al. 2011

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Twenty-two novel N-nitro-N 0 -substituted phenyl-N-(2,6-dibromo-4-fluorophenyl)urea derivatives were designed and synthesized via a simple and convenient BTC 'one-pot' procedure using DMAP as the catalyst. The structures of all newly synthesized compounds were confirmed by IR, 1 H NMR, and elemental analysis, and a part has been identified by 13 C NMR. The preliminary bioassay indicates that the target compounds possesses moderate herbicidal activity against Sorghum sudanense. However, some of the title compounds presented high plant growth regulating activity against rape.

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“…Benzoxazole derivatives exhibits anthelmintic 1 , antiulcer 2 , antitumor 3 , antimicrobial 4,5 andanticancer 6 activities. Benzoxazole containing compounds are also acts as RSK2 inhibitor 7 and  1 -AR antagonist 8 .…”

Section: Introductionmentioning

confidence: 99%