Synthesis and antimicrobial activity of tryptanthrin adducts with ketones

Recent advances of tryptanthrin and its derivatives as potential anticancer agents

“…The substitution of halogen, alkyl and alkoxy groups onto the A and D aromatic rings has been investigated by Liu, Sharma and other groups. [49][50][51][52][53][54][55][56][57][58][59][60][61][62] A series of substituted tryptanthrins (11)(12)(13)(14)(15)(16)(17)(18)(19) are prepared by the optimized Bergman condensation reaction of substituted isatins with substituted isatoic anhydrides (Scheme 3). The usage of substituted anilines as reaction materials to prepare substituted isatin derivatives needs two steps.…”

“…Table 1 Cytotoxicity of 1-43 toward cancer cell lines after an incubation time of 24 h (or 48 h) [1][2][3][4][5][6][7][8][9][10][11][12][13][14][15][16][17][18][19][49][50][51][52][53][54]56,[59][60][61][62][63][64][65][66][67][68]101,126…”

“…11 Subsequently, the study on tryptanthrin alkaloid was discussed in another review article in 2013, where various synthetic methods were applied for the preparation of tryptanthrin. 12a Owing to its pharmacologically aromatic indoloquinazoline moiety with a wide range of biological and pharmacological activities, tryptanthrin has been extensively applied as a parental backbone via the modification of different functional groups for the development of new tryptanthrin derivatives with significant medicinal benefits as antitrypanosomal, 13 antifungal, 14,15 anti-phytopathogenic bacterial, 16 antibacterial, [17][18][19][20][21] anti-MRSA, 22 antiviral, [23][24][25][26] antiangiogenic, 27 anti-inflammatory, [28][29][30][31][32][33][34][35][36][37][38][39] anti-leishmanial, 40,41 antimalarial, 42 antiplasmodial, 43 antiparasitic, 44 antitubercular, [45][46][47] and anti-cancer [48][49][50][51][52][53][54]…”

Triptantrina: da Natureza ao Laboratório

“…Como se referiu na introdução, os extratos naturais contendo triptantrina são utilizados desde a antiguidade pelas suas propriedades terapêuticas, sendo conhecida desde longa data a sua capacidade de atuar como anti-inflamatório, antipirético e analgésico [23,24]. Para além destas, a triptantrina é ainda conhecida pela sua atividade como agente anti-infecioso, demonstrando atividade contra fungos, parasitas (incluindo-se nestes os agentes causadores da malária e da leishmaniose), bactérias (nomeadamente a Mycobacterium tuberculosis), anticancerígeno e anti-inflamatório [25][26][27][28][29][30][31].…”

Tryptanthrin derivatives as efficient singlet oxygen sensitizers

“…In the past recent years different TRYP derivatives [12][13][14][15][16][17][18] as well as its nanoformulations [19] have been synthetized and evaluated for potential biological and pharmacological activity, e.g. antipathogenic, antifungal, antiparasitic, antitubercular, antimalarial, anticancer, antioxidant, and anti-inflammatory [13,[20][21][22][23][24][25][26][27][28][29] and, very interesting, as stable active materials for all-organic redox flow batteries [30]. Most of these studies revealed that modification of TRYP core is important to develop novel and widespread potential applications in various fields.…”