Synthesis and antimicrobial activity of 2-aryl-substituted 4,7-dihydro- and 4,5,6,7-tetrahydroisoindoles

4,7-Dihydro-, 4,5,6,7-tetrahydro-, and octahydroisoindoles (and methanoisoindoles). (Review)

“…We made a systematic pharmacological study of the biological characteristics of isoindoles [43,[59][60][61][62][63][64][65][66][67]69]. As a result of the tests substances with neurotropic, hypotensive, radioprotective, diuretic, bactericidal, antihelminthic, and fungicidal characteristics were found.…”

“…The formylation of 2-phenyl-4,7-dihydro-and 4,5,6,7-tetrahydroisoindoles 51 by the VilsmeierHaack method was described in [58,59]. The aldehydes 51a were obtained with yields of 52-75%, and their functional derivatives (semicarbazones and 2,4-dinitrophenylhydrazones) were obtained with quantitative yields.…”

“…The recyclization of diene condensation adducts based on methoxydihydrofurans with primary amines has found use in the synthesis of biologically active compounds having specific characteristics [43,[59][60][61][62][63][64][65][66][67][68][69] and also in the production of the 4,5,6,7-tetrahydroisoindole fragments of porphyrins [70].…”