Synthesis and antimicrobial activity of coordination compounds of 3d-elements with N1-2-and N1-3-picolidene-N3-phenylpicolinamidrazones

Samus, N. M.; Toleva, A. D.; Tsapkov, V. I.; Burdenko, T. A.; Videlingam, Anvar Khossen

doi:10.1007/bf00767667

Cited by 3 publications

(3 citation statements)

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“…The preparation of amidrazones was reported by different methods such as addition of sodium hydrazide to nitriles [10], reaction of nitrohydrazones with amines [11], and enzymatic methodologies [12]. Amidrazones can be used as versatile ligands and their complexes were shown antibacterial [13], antitumor [14], and insulin-mimetic activities [15]. The importance of amidrazones revealed more when their anticancer [16,17] and enzymatic inhibitory [18,19] properties were observed.…”

Section: Introductionmentioning

confidence: 99%

DFT and MP2 study of simple and water-assisted tautomerism in amidrazones

Tavakol

2011

Struct Chem

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DFT and MP2 methods were used to calculate structural parameters, vibrational modes, solvent effect, and energetic properties of amidrazones. Amidrazones can be presented by three tautomeric forms and six isomers. All tautomers and transition states were optimized at the B3LYP/6-311??g** and MP2/6-311??G** levels of theory. The relative stabilities of amidrazone isomers in the gas phase were found to be as 1Z. The calculated energy differences between E and Z isomers are very low and between different tautomers are nearly low, but the energy barriers for tautomerism interconversions at the gas phase are high. The kinetic and thermodynamic data in solvents (chloroform, tetrahydrofuran, acetone, and water) are nearly similar to those in the gas phase but their rate constants are slightly less than those in the gas phase. Moreover, equilibrium and rate constants of intermolecular tautomerism in presence of 1-3 molecules of water were calculated. Computed energy barriers show that the barrier energy of water-assisted tautomerism is very lower than that in simple tautomerism and also calculated binding energies show that water can stabilize transition states more than tautomers. Therefore, this water-assisted tautomerism can be performed fast, especially with the assistance of two molecules of water.

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Section: Introductionmentioning

confidence: 99%

DFT and MP2 study of simple and water-assisted tautomerism in amidrazones

Tavakol

2011

Struct Chem

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“…These properties made them useful in design and synthesis of novel functional materials [23,24]. Furthermore, amidrazone derivatives are of interest as ligands in medicinal chemistry following the reports on antitumor properties of their Cu(II), Au(III) and Pt(II) complexes [25][26][27] or antibacterial [28,29], antimalarial [30] and insulinmimetic activities [22] of many other 3d transition metal complexes.…”

Section: Introductionmentioning

confidence: 99%

Synthesis, crystal structure and biological activities of a novel amidrazone derivative and its copper(II) complex — A potential antitumor drug

Mazur

Modzelewska-Banachiewicz

Paprocka

et al. 2012

Journal of Inorganic Biochemistry

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“…Derivatives of amidrazones are interesting ligands in the light of reports on the antibacterial activity of 3d transition metal complexes of picolinamidrazones [29] and the antibacterial and antitumoral activity of Pt 2+ complexes with N 1 -phenylsubstituted amidrazones [30]. The properties of the complexes formed by N 1 -acylacetamidrazones and N 1 -acyl-2-phenylacetamidrazones with Pd 2+ , Pt 2+ and Pt 4+ ) have been studied several years ago [31].…”

Section: Introductionmentioning

confidence: 99%