2015
DOI: 10.1248/cpb.c14-00521
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Synthesis and Antimicrobial Activity of Amino Linked Heterocycles

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Cited by 7 publications
(2 citation statements)
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“…In addition, as an important pharmacophore, quinazoline has a variety of biological activities such as anticancer , antibacterial , and anti‐inflammatory , Although the medicinal chemistry fraternity has put up a brave front to cover a wide range of structurally and functionally derivatized heterocyclic compounds, the libraries of bis and tris heterocycles have not been extensively studied. Fascinated by multifarious bioactivity of these heterocycles and our continued efforts in this direction , we planned to synthesize compact molecules encompassing benzazole and quinazoline entities conjugated by a heteroatom with a scope to develop compounds possessing noteworthy pharmacological properties.…”
Section: Introductionmentioning
confidence: 99%
“…In addition, as an important pharmacophore, quinazoline has a variety of biological activities such as anticancer , antibacterial , and anti‐inflammatory , Although the medicinal chemistry fraternity has put up a brave front to cover a wide range of structurally and functionally derivatized heterocyclic compounds, the libraries of bis and tris heterocycles have not been extensively studied. Fascinated by multifarious bioactivity of these heterocycles and our continued efforts in this direction , we planned to synthesize compact molecules encompassing benzazole and quinazoline entities conjugated by a heteroatom with a scope to develop compounds possessing noteworthy pharmacological properties.…”
Section: Introductionmentioning
confidence: 99%
“…It occurs in various natural products and is used in the core structure of many pharmaceutical drugs such as alfuzosin, prazosin, terazosin, and doxazosin. , Because of the versatile applications of quinazolinedione, countless efforts have been expended to develop a cost-effective, clean, and green route to the synthesis quinazolinedione and its derivatives. Conventional methods for its synthesis mainly include the condensation of anthranilic acid with urea and potassium cyanate . It is also synthesized by the oxidation of spirocyclic oxindole, carbonylation of o -nitrobenzamide, , and the reaction of isatoic anhydride with urea .…”
Section: Introductionmentioning
confidence: 99%