Synthesis and Antimicrobial Activity of Some New 2-Phenyl-N-substituted Carboxamido-1H-benzimidazole Derivatives

Abstract

Some 1H‐benzimidazole‐carboxamide derivatives were prepared and their antimicrobial activities against Staphyloccus aureus, Escherichia coli and Candida albicans evaluated. Compounds 18, 22, and 25 exhibited the best activity against Candida albicans.

Synthesis, Characterization and Antibacterial Evaluation of some Novel Benzimidazole Derivatives Containing 1,3,4-Thiadiazole Moiety.

“…21 Despite of many attempts to develop and discover new structural type in the search for great and more effective antimicrobials, benzimidazoles still consider as one of the most versatile and significant type of compounds against microbes. 22,23 The benzimidazole containing compounds as a structural motif have been widely used in medicinal chemistry and drugs development. Amongst the benzimidazole derivatives 2-chloromethyl benzimidazole show a considerable importance in biological chemistry, they are important intermediates in the synthesis of many biologically active compounds.…”

Synthesis, Characterization, Molecular Docking Studies and Antimicrobial Evaluation of N-Benzimidazol-1-Yl-Methyl-Benzamide Derivatives

“…1 The main cause of microbial resistance is the mutations or transfer of resistant genes between organisms. 2 Resistant microbes may require other medications or elevated doses associated with more side effects, some of which may be life alarming.…”

Synthesis and biological activity evaluation of 1H-benzimidazoles via mammalian DNA topoisomerase I and cytostaticity assays

“…These compounds have been intensively studied over last years because of their antibacterial [1], antifungal [2], antimicrobial [3], antiprotozoal [4] and antihelmintic [5] activities. Some benzimidazole derivatives are also active as type I DNA topoisomerase inhibitors [6,7].…”