Synthesis and antimicrobial activity of some novel 2,5- and/or 6-substituted benzoxazole and benzimidazole derivatives

Coordination behavior of benzimidazole, 2-substituted benzimidazoles and benzothiazoles, towards transition metal ions

“…28a While 3-hydroxybenzoic acid stabilizes two independent molecules in the unit cell: one of them is a mononuclear compound with the copper(II) atom in a square-planar coordination geometry formed by two benzimidazole molecules and two hydroxylbenzoate anions, stabilizing a trans isomer as observed in the previously described [Cu(bz) 2 Br 2 ], Figure 10b. 28b The other molecule is a dimer of the previous one, formed by bridging hydroxybenzoate, where de copper(II) is in a square-pyramidal geometry.…”

“…Figure 19 some of the tautomers and conformers of 2-uroyl-benzimidazole are represented, 37a and the structure of 2-benzimidazolecarbamate. Despite of the presence of oxygen atoms as possible coordinating sites towards transition metal ions, both ubz and mbc derivatives behaved as monodentate ligands, bonded through the benzimidazolic nitrogen to the metal atom, as illustrated by the carbamate (mbc) compound, [Co(mbc) 2 are shown in Figure 25. The copper(II) complex is a monomer, with a ligand and two chlorine atoms bonded to the metal ion, in a tetrahedral geometry.…”

“…The crystal space group is P 1 therefore, the crystal must contain a racemic mixture of the Λ and ∆ isomers. 2 ]⋅2MeOH (2) is obtained; here each metal ion presents a square pyramidal geometry. In this case, the deprotonated benzimidazole ligands are coordinated through two nitrogen atoms, as in the previous compound, where two copper(II) ions are bridged by crotonate oxygen atoms forming a rectangular arrangement, while the other two copper(II) ions are linked by bridging oxygen atoms from two crotonate groups and a methanol molecule occupies the apical position of the square pyramid, Figure 36a.…”

Synthesis and anticancer activity evaluation of N-[4-(2-methylthiazol-4-yl)phenyl]acetamide derivatives containing (benz)azole moiety

“…In addition to thiazoles, some other azole compounds have also attracted much attention due to their prominent utilization as antitumor agents 21 . For instance, derivatives of triazole 22 , imidazole 23 , benzimidazole 24,25 , benzoxazole [26][27][28] and benzothiazole 29 have shown anticancer properties. Triazole derivatives anastrozole and letrozole are the aromatase inhibitors, currently finding widespread application in the clinic 30 .…”

Synthesis and Pharmacological Evaluation of Some Novel 2-Mercapto Benzimidazole Derivatives

“…Exclusive literature survey of benzimidazole and triazole 1,2 brevealed that it has diversified activities such as anticonvulsant, 3−5 antihelmenthic, 6 antiamoebic, 7 antiparasitic, 8 as potent H3 antagonist, 9 potential anxiolytic agent, 10 cyclooxygenase inhibitors, 11 anticancer, 12 spasmolytic activity, 13 antithyroid activity, 14 antimicrobial and antifungal, 15 androgen receptor antagonist. 16 The antiprotozoal activity of substituted 2-trifluorobenzimidazoles has been reported 17 consistent with several earlier studies on the anti-giardial activity of various benzimidazole derivatives.…”