Synthesis and Antimicrobial Evaluation of Some Novel 2‐Aminothiazole Derivatives of 4‐Hydroxy‐chromene‐2‐one

Abstract

Syntheses of 2-aminothiazole derivatives of 4-hydroxy-chromene-2-one 2c-10c are reported in this paper. These compounds 2c-10c were prepared from 3-(2-bromoacetyl)-4-hydroxy-chromene-2-one 1 and corresponding thiourea derivatives 2b-10b using Hantzsch reaction. The structures of all compounds were confirmed by IR and( 1)H-NMR spectroscopy and elemental analyses. The molecules 2c-10c were evaluated for in vitro antimicrobial activity against ten bacteria and twelve fungi. All tested compounds exhibited antibacterial and antifungal activity.

Synthesis and Biological activity of 1,3-Thiazolylidenehydrazinylidene ethylpyridiniumbromide monohydrate, 1,3-Thiazolylidenehydraziniumbromide and 1,3-Thiazolylidenehydrazine derivatives

“…1) [35]. The dihedral angle between S1/N1C1-C3 thiazolylidene and N4/C18-C22 pyridinium rings is 14.73 C(3)o while that between the phenyl groups C4 -C9 and C10-C15 and the mean plane of the thiazolylidene ring are 34.69 (13) On the other hand, 2- , respectively with the (S1/N1/C7-C9) thiazole ring ( Fig. 2) [36].…”

“…The occurrence of thiazole ring system in numerous biologically active molecules have recognized and possess wide ranges of biological properties such as antioxidant [8], antibacterial drugs [9 -11], fungicidal treatment [3,12], antiinflammatory [13][14][15][16], anticonvulsant [17], and anti-HIV [18][19][20]. 2-Aminothiazole was used as inhibitors of human cancer and Alzheimer's disease [21][22][23][24].…”

“…3h showed the highest inhibitory effect against all types of bacterial compared to Moxiflo xacin. The structures of synthesized compounds were established by spectroscopic (IR, 1 H,13 C-N MR, Mass) and X-ray analyses. …”

Synthesis and Characterization of the Polymeric Phenolic Schiff Bases Containing Aminothiazole Moiety

“…As ligands, they also provide many potential binding sites for complexation of diverse metal ions like Cu(II), Co(II), Ni(II), or Zn(II) among others with well established biological roles [3][4][5][6][7][8][9] . It is also a well known fact that aminothiazoles and aminothiazole Schiff bases have very good antibacterial, antiviral and anti fungal property and upon complexation with metal ions its antibacterial antiviral and antifungal properties increases many folds [10][11][12][13][14] . Therefore Schiff-bases of amino thiazoles and RESEARCH ARTICLE their transition metal complexes are found to be of great interest in co-ordination chemistry as well as pharmaceuticals chemistry [15][16][17][18] .…”

Antimicrobial and Anti-biofilm Activity of Thiourea Derivatives Incorporating a 2-Aminothiazole Scaffold

“…Especially 2-amino-1,3-thiazole scaffold (fused and non-fused) would serve as a privileged structure due to their prevalence in antibacterial agents and other biologically active molecules. [1][2][3][4][5] Database of biologically active substances 6) reveals the extensive use of the 2-aminothiazole structural motif in numerous applied drugs as well as in preclinical and clinical candidates (e.g., Sulfatizole, Cetraxone, Aztreonam, Riluzole).…”