Synthesis and antimycobacterial activity of a series of ferrocenyl derivatives

Mwande-Maguene, Gabin; Jakhlal, Jouda; Ladyman, Melissa; Vallin, Aurélie; Ralambomanana, Dimby Andrianina; Bousquet, Till; Maugein, J.; Lébibi, Jacques; Pélinski, Lydie

doi:10.1016/j.ejmech.2010.10.004

Cited by 59 publications

(32 citation statements)

References 29 publications

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“…During the first two decades of the 21st century, special attention was paid to the synthesis and bioassay of ferrocene derivatives carrying pharmacophoric groups, namely, nucleic bases, oligonucleotides, various heterocycles, amino acids, peptides, and sugars . In vitro and in vivo studies have demonstrated that many of such modified ferrocenes display a wide spectrum of biological activities, including antianemic, antimicrobial, antibacterial, antimalarial, tuberculostatic, and especially antitumor activities, see recent review articles . Ferroceron (tetrahydrate of sodium salt of ortho ‐carboxybenzoyl ferrocene), which is the first and only currently ferrocene‐based drug, has been effectively used for a long time for the treatment of iron deficiency pathologies .…”

Section: Introductionmentioning

confidence: 99%

Administration of ferrocene‐modified amino acids induces changes in synaptic transmission in the CA1 area of the hippocampus

Rodionov

Snegur

Dobryakova

et al. 2019

Applied Organom Chemis

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A series of ferrocene‐modified amino acid methyl esters with pyrazole linker was prepared in good to quantitative yields starting from easy accessible ferrocene pyrazole carbaldehyde and amino acids in racemic and enantio enriched forms under reductive amination conditions (NaBH (OAc)3, reflux, 3 hr). The resulting enantiomers were resolved using analytical HPLC on modified cellulose or amylose as chiral selectors. In vivo electrophysiological experiments were performed in the CA1 field of the hippocampus on 3a Fc‐Gly, (L)‐3b Fc‐Ala, and (D)‐3b Fc‐Ala compounds. An increasing in the amplitudes of responses of local potentials (up to 25%) of the CA1 region in the studied groups was found after intraperitoneal administration of ferrocene compounds 3a and (D)‐3b compared with control rats treated with saline.

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Section: Introductionmentioning

confidence: 99%

Administration of ferrocene‐modified amino acids induces changes in synaptic transmission in the CA1 area of the hippocampus

Rodionov

Snegur

Dobryakova

et al. 2019

Applied Organom Chemis

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“…It can be easily derivatized and functionalized or oxidized to ferricenium salts. Many ferrocenyl compounds showed good results toward cytotoxic activity, antitumor, antimalarial, antifungal and DNA‐cleaving activity …”

Section: Introductionmentioning

confidence: 99%

Synthesis, characterization and anticancer studies of ferrocenyl complexes containing thiazole moiety

Abd-Elzaher

Moustafa

Labib

et al. 2012

Applied Organom Chemis

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A ferrocenyl ligand was prepared from condensation of l,l′-diacetylferrocene with 2-amino-5-methylthiazole, to give the ligand. This ligand forms 1:1 complexes with lead(II), cobalt(II), nickel(II), copper(II) and zinc(II) in good yield. Characterization of the ligand and complexes was carried out using IR, NMR, electronic absorption, magnetic susceptibility, molar conductivity and elemental analysis. Anticancer activity of the prepared ligand and its complexes against breast cancer cell line MCF-7 was determined. The anticancer activity of the new complexes was accompanied by significant increase in the activity of superoxide dismutase, with a parallel decrease in the activities of catalase and glutathione peroxidase and reduced glutathione level. Accordingly, the overproduction of free radicals allowed reactive oxygen species-mediated cancer cell death. The results suggest that the complexes possess significant anticancer activity comparable to cisplatin.

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“…Among compounds of this type, hydrazones containing ferrocenyl fragment are of special interest, some of which show second order non-linear optical properties [10][11][12] or biological activity [13][14][15]. Numerous complexes based on hydrazones of carbonyl ferrocene derivatives were described [16][17][18][19][20][21][22][23][24], whereas ferrocenoylhydrazones of carbonyl compounds are much less studied [25][26][27][28][29].…”

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confidence: 99%

Ferrocenoylhydrazone of 2-N-tosylaminobenzaldehyde: Structure, properties, and complexing ability

et al. 2015

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2-N-Tosylaminobenzaldehyde ferrocenoylhydrazone was synthesized. The crystal structure of the hydrazone was shown to include two independent molecules differing in mutual orientation of the tosyl and ferrocene fragments. Quantum-chemical simulation of the hydrazone tautomerism was performed. Its complexes with Cu(II), Ni(II), Zn(II), and Cd(II) were synthesized and investigated. POPOV et al. 132 coordinates and temperature factors were deposited in the Cambridge Crystallographic Data Center (CCDC 981876).

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Synthesis and antimycobacterial activity of a series of ferrocenyl derivatives

Cited by 59 publications

References 29 publications

Administration of ferrocene‐modified amino acids induces changes in synaptic transmission in the CA1 area of the hippocampus

Administration of ferrocene‐modified amino acids induces changes in synaptic transmission in the CA1 area of the hippocampus

Synthesis, characterization and anticancer studies of ferrocenyl complexes containing thiazole moiety

Ferrocenoylhydrazone of 2-N-tosylaminobenzaldehyde: Structure, properties, and complexing ability

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