Synthesis and antimycobacterial evaluation of natural oridonin and its enmein-type derivatives

Xu, Shengtao; Pei, Lingling; Li, Dahong; Yao, Hong; Cai, Hao; Yao, Hequan; Wu, Xiaoming; Xu, Jinyi

doi:10.1016/j.fitote.2014.10.005

Cited by 38 publications

(29 citation statements)

References 12 publications

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“…In some studies, diterpenes in nanoformulations (Roy et al ., ; Mondal et al ., ) as well as their laboratory derivatives have been reported to exhibit promising anti‐NTDs activities (Watson and Preedy, ; Mander and Liu, ). Additionally, a number of diterpenes have been reported to act against multiple strains responsible for a particular NTD (Sanchez et al ., ; Dea‐Ayuela et al ., ; Johnson et al ., ; Riel et al ., ; Clarkson et al ., ; Kalauni et al ., ; Ojo‐Amaize et al ., ; Wangchuk et al ., ; González et al ., ; Namukobe et al ., ; Liu et al ., ; Prabu et al ., ; Encarnación‐Dimayuga et al ., ; Rijo et al ., ; Arai et al ., ; Xu et al ., ; Xu et al ., ) and NTDs (Schmidt et al ., ; Al Musayeib et al ., ; Ramírez‐Macías et al ., ; Mothana et al ., ; Falodun et al ., ; Mizuno et al ., ; Mongkolvisut and Sutthivaiyakit, ; Rangkaew et al ., ; Ospina and Rodríguez, ; Lekphrom et al ., ; Almutairi et al ., ).…”

Section: Discussionmentioning

confidence: 99%

Diterpenes as lead molecules against neglected tropical diseases

et al. 2016

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Nowadays, neglected tropical diseases (NTDs) are reported to be present everywhere. Poor and developing areas in the world have received great attention to NTDs. Drug resistance, safety profile, and various challenges stimulate the search for alternative medications. Plant-based drugs are viewed with great interest, as they are believed to be devoid of side effects. Diterpenes, a family of essential oils, have showed attractive biological effects. A systematic review of the literature was carried out to summarize available evidences of diterpenes against NTDs. For this, databases were searched using specific search terms. Among the 2338 collected reports, a total of 181 articles were included in this review. Of them, 148 dealt with investigations using single organisms, and 33 used multiple organisms. No mechanisms of action were reported in the case of 164 reports. A total of 93.92% were related to nonclinical studies, and 4.42% and 1.66% dealt with preclinical and clinical studies, respectively. The review displays that many diterpenes are effective upon Chagas disease, chikungunya, echinococcosis, dengue, leishmaniasis, leprosy, lymphatic filariasis, malaria, schistosomiasis, and tuberculosis. Indeed, diterpenes are amazing drug candidates against NTDs. Copyright © 2016 John Wiley & Sons, Ltd.

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Section: Discussionmentioning

confidence: 99%

Diterpenes as lead molecules against neglected tropical diseases

et al. 2016

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“…Based upon the multifunctional effects of CDDO-Me, researchers explored different indications in clinical trials, including the treatments of chronic kidney disease (Phase II, NCT02316821), pulmonary arterial hypertension (Phase III, NCT02657356), and advanced malignant melanoma (Phase II, NCT00535314). Hence, additional attention should also be paid to explore other beneficial effects, including cytoprotection [40], anti-mycobacterial [126, 127], anti-fibrosis [128, 129] and anti-inflammatory effects [130], produced by oridonin and its derivatives. Interestingly, recent findings support that oridonin and its analogues may be considered a promising therapeutic option for Alzheimer’s disease (AD) and other neurodegenerative diseases [41, 42].…”

Section: Conclusion and Future Perspectivesmentioning

confidence: 99%

Discovery and development of natural product oridonin-inspired anticancer agents

Ding

et al. 2016

European Journal of Medicinal Chemistry

153

104

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Natural products have historically been, and continue to be, an invaluable source for the discovery of various therapeutic agents. Oridonin, a natural diterpenoid widely applied in traditional Chinese medicines, exhibits a broad range of biological effects including anticancer and anti-inflammatory activities. To further improve its potency, aqueous solubility and bioavailability, the oridonin template serves as an exciting platform for drug discovery to yield better candidates with unique targets and enhanced drug properties. A number of oridonin derivatives (e.g. HAO472) have been designed and synthesized, and have contributed to substantial progress in the identification of new agents and relevant molecular mechanistic studies toward the treatment of human cancers and other diseases. This review summarizes the recent advances in medicinal chemistry on the explorations of novel oridonin analogues as potential anticancer therapeutics, and provides a detailed discussion of future directions for the development and progression of this class of molecules into the clinic.

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“…There is a clear and desperate need for new medicines to treat TB. As working with M. tuberculosis limits research and preclinical drug development to those laboratories around the world with the resources and facilities to safely handle the bacterium, non-tuberculous mycobacteria such as M. marinum are widely used as surrogates 5, 7, 41, 42 . A major drawback of using M. marinum for antimycobacterial compound screening is that the in vitro resistance profile of the bacterium is very different to M. tuberculosis .…”

Section: Discussionmentioning

confidence: 99%