Synthesis and Antinociceptive Activity of Substituted 5-(Het)aryl-3-(4-methylbenzoyl)hydrazono-3H-furan-2-ones

Synthesis and Characterization of Hybrid Structures Based on Furan-2(3H)-ones and Chromen-4(4H)-ones—Potential Antibacterial Activity

“…The focus of this study is on the synthesis of hybrid molecules based on furan-2(3H)ones and 4-oxo-4H-chromene-3-carbaldehyde. Furan-2(3H)-one derivatives are found among a large number of compounds that have antinociceptive, anti-inflammatory, antiviral and antitumor effects [14][15][16][17]. It is important to note nitrofuran derivatives, which have pronounced antibacterial activity [18][19][20][21][22].…”

Synthesis, recyclization under the action of methanol and analgetic activity of N'-(5-aryl-2-oxofuran-3(2H)-ylidene)furan-2-carbohydrazides

“…This fragment was found in the structure of various biologically active and natural compounds [33,34], which indicates that this idea is worth developing. Previously, we proposed a simple method for the preparation of 3-hydrazinylidenefuran-2(3H)-one derivatives by intramolecular cyclization of substituted 2-[2-(4-Rbenzoyl)hydrazinylidene]-4-oxobutanoic acids in the presence of acetic or propionic anhydride [35,36]. Furthermore, this method was applied to 3-imino(thiophen-2-yl)furan-2(3H)-ones derivatives, which include the pharmacophore fragment, Gewald aminothiophene [37][38][39][40][41].…”

Synthesis, intramolecular cyclization and anti-inflammatory activity of substituted 2-(2-(Furan-2-carbonyl)hydrazono)-4-oxobutanoic Acids

“…Previously, we proposed a simple method for the preparation of 3-hydrazinylidenefuran-2(3Н)-one derivatives by intramolecular cyclization of substituted 2-(2-(4-R-benzoyl)hydrazono)-4-oxobutanoic acids in the presence of acetic or propionic anhydride [28,29]. Furthermore, this method was applied to the synthesis of 3-(imino(thien-2-yl))furan-2(3H)ones derivatives, which include the pharmacophore fragment, Gewald aminothiophene [30] (Scheme 1).…”