Synthesis and Antioxidant Evaluation of Novel Phenothiazine Linked Substitutedbenzylideneamino-1,2,4-Triazole Derivatives

Abstract

A series of novel 5-((10H-phenothiazin-10yl)methyl)-4-(substitutedbenzylideneamino)-4H-1,2,4-triazole-3-thiol derivatives (6a-i) have been synthesized from compound (1) through a multi-step reaction. The key intermediate (5) afforded a series of title compounds (6a-i) on condensation with various suitable aldehydes in the presence of H 2 SO 4 . The structures of novel compounds were characterized based on their elemental analysis, IR, 1 H-NMR, 13 C-NMR and MS spectral data. All these novel compounds were screened for their in vitro antioxidant activity by employing nitric oxide, hydrogen peroxide, and DPPH radical scavenging assays. The compounds 6d, 6e and 6i demonstrated potent antioxidant activity as these contain the electron-releasing groups.

Potential Antioxidant Activity of New Tetracyclic and Pentacyclic Nonlinear Phenothiazine Derivatives

“…Their activity was comparable to that of the reference compound (ascorbic acid) ( Table 1 ). This is due to the presence of sulfur in their structures which reduces hydrogen peroxide to sulphoxide as suggested by previous studies [ 44 , 45 ]. This ability of phenothiazine derivatives to inhibit hydrogen peroxide has been shown by Maddila and collaborators as their newly synthesized phenothiazine linked substituted benzylideneamino-1,2,4-triazole derivatives had the potentials to scavenge hydrogen peroxide [ 46 ].…”

The structural elucidation and antimicrobial activities of two new monoterpene glucoside derivatives from Lomatogonium carinthiacum (Wulf) Reichb

“…The discs were then placed on soft nutrient agar (2%) Petri plates previously seeded with suspension of each bacterial species. The diameter of the zone of inhibitions was measured at 37 ± 1 °C after 24 h. For antifungal activity, Saboraud's broth medium with 4% agar was used for the preparation of plates and incubated with spores and mycelium suspension of fungi obtained from 1‐week‐old culture. The diameter of zones of inhibition was measured at 28 ± 1 °C after 48 h. The results are recorded in Table .…”

Synthesis, Biological Activity of Pyrimidine Linked with Morpholinophenyl Derivatives

“…Among them dengue fever is the most dangerous and case list is also increasing day by day . In the last five years most of the insecticides did not show any effect on insects like mosquitoes because of increased drug resistance .…”