Synthesis and antioxidant properties of substituted 2-phenyl-1H-indoles

Karaaslan, Çiğdem; Kadri, Hachemi; Çoban, Tülay; Süzen, Síbel; Westwell, Andrew D.

doi:10.1016/j.bmcl.2013.02.090

Cited by 44 publications

(18 citation statements)

References 28 publications

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“…Synthesis of quinoline-2-carboxaldehyde hydrazones. Figure 1. (a) Melatonin, (b) melatonin analogue indole-3-carboxaldehyde hydrazones that have higher antioxidant activity than MLT 4,[6][7][8][9] . 1H, d, H-3), 8.33 (1H, d, H-4 …”

Section: Methodsmentioning

confidence: 99%

“…Reactive oxygen species (ROS) and reactive nitrogen species are well known as both harmful and beneficial species. Oxidative stress that gives increase to generation of mainly ROS has been connected with an extensive range of diseases including those of cardiovascular, inflammatory, neurodegenerative, and autoimmune origin 4,5 .…”

Section: Introductionmentioning

confidence: 99%

“…In our ongoing study, we have synthesized various series of indole derivatives, with some modifications on MLT ( Figure 1) 4,[6][7][8][9] . The synthesized bioisosteric MLT analogues have been evaluated for their potential radical scavenging activity and protective effect against oxidative damage 4,[6][7][8][9] .…”

Section: Introductionmentioning

confidence: 99%

“…The synthesized bioisosteric MLT analogues have been evaluated for their potential radical scavenging activity and protective effect against oxidative damage 4,[6][7][8][9] . A review on the structure activity relationship of several of these derivatives has been previously published by Suzen 12 .…”

Section: Introductionmentioning

confidence: 99%

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Synthesis and evaluation of antioxidant activity of new quinoline-2-carbaldehyde hydrazone derivatives: bioisosteric melatonin analogues

Püsküllü

Shirinzadeh

Nenni

et al. 2015

Journal of Enzyme Inhibition and Medicinal Chemistry

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Overproduction of reactive oxygen species results in oxidative stress that can cause fatal damage to vital cell structures. It is known that the use of antioxidants could be beneficial in the prevention or delay of numerous diseases associated with oxidative stress. Melatonin (MLT) is known as a powerful free-radical scavenger and antioxidant. It was found that indole ring of MLT can be employed by bioisosteric replacement by other aromatic rings. Quinoline derivatives constitute an important class of compounds for new drug development. Owing to quinoline and hydrazones appealing physiological properties and are mostly found in numerous biologically active compounds a series of quinoline-2-carbaldehyde hydrazone derivatives were synthesized as bioisosteric analogues of MLT, characterized and in vitro antioxidant activity was investigated by evaluating their reducing effect against oxidation of a redox-sensitive fluorescent probe. Cytotoxicity potential of all compounds was investigated both by lactate dehydrogenase leakage assay and by MTT assay.

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Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Synthesis and evaluation of antioxidant activity of new quinoline-2-carbaldehyde hydrazone derivatives: bioisosteric melatonin analogues

Püsküllü

Shirinzadeh

Nenni

et al. 2015

Journal of Enzyme Inhibition and Medicinal Chemistry

Self Cite

View full text Add to dashboard Cite

show abstract

“…Antioxidants are recently invented as the drug candidates to counter these diverse diseases, such as carcinogenesis, inflammation, and aging in aerobic organisms [4]. The design of small molecular agents to conflict cellular oxidative stress has become an important therapeutic objective, towards comprehensive damage to cellular macromolecules caused by reactive oxygen species (ROS) [5]. The extensive action of synthetic antioxidants is being ruled out owing to their toxicity and unwanted side effects and there is a growing interest in the use of the natural product as antioxidants and their derivatives for the treatment of oxidative stress-related diseases [6].…”

Section: Introductionmentioning

confidence: 99%