Synthesis and antioxidant properties of 3-methyl-substituted thiazolo[3,2-a]benzimidazole

4-[1-(Substituted aryl/alkyl carbonyl)-benzoimidazol-2-yl]-benzenesulfonic acids: Synthesis, antimicrobial activity, QSAR studies, and antiviral evaluation

“…The appearance of singlet around 2.5 d ppm corresponds to the proton of SO 3 H in the NMR of all the compounds indicated the presence of para sulfonyl phenyl nucleus to the 2nd position of synthesized benzimidazoles (11)(12)(13)(14)(15)(16)(17)(18)(19)(20). Further the multiplet corresponds to 6 chloride of methacrylic acid.…”

“…The appearance of C]O stretch in the range of 1630e1600 cm À1 indicated the formation of tertiary amides (1)(2)(3)(4)(5)(6)(7)(8)(9)(10)(11)(12)(13)(14)(15)(16)(17)(18)(19)(20) by the reaction of acid chlorides with the 4-(1H-benzoimidazol-2yl)-benzenesulfonic acid. The primary amino group in compound 1 is depicted by the presence of NH asymmetric stretch at 3481.81 cm À1 .…”

“…Furthermore, the topological parameter, Balaban index (J) followed by the electronic parameter, LUMO and topological parameter, valence second order molecular connectivity index ( 2 c v ) is describing the antimicrobial activity of 4-[1-(substituted aryl/alkyl carbonyl)-benzoimidazol-2-yl]-benzenesulfonic acids (1)(2)(3)(4)(5)(6)(7)(8)(9)(10)(11)(12)(13)(14)(15)(16)(17)(18)(19)(20).…”

Thiazolo[3,2-a]benzimidazoles: Synthetic Strategies, Chemical Transformations and Biological Activities

“…Compounds 197 were prepared from the reaction of 3-chloromethythiazolo[3,2- a ]benzimidazole ( 196 ) with 2-mercaptobenzimidazole 3 [ 91 ], while 3-aminomethylthiazolo[3,2- a ]benzimidazoles 198 were synthesized by reacting 3-(chloromethyl)thiazolo[3,2- a ]benzimidazole 196 with primary and secondary amines [ 92 ] Recently, β -methyl carbapenem incorporating thiazolobenzimidazole moiety compound 200 [ 93 ] was prepared from lactame 199 ( Scheme 55 ).…”

Synthesis of novel thiazolobenzimidazoles

“…• The introduction of some substituents either on the benzene cycle of the thiazolobenzimidazole or on the thiazole ring (Chen et al, 2003;Sissouma et al, 2005;Mavrova et al, 2006;Dianov, 2007;Gabillet et al, 2007). This alteration in the structure of the main model compounds could be used to determine the influence of different substituents over the antitrichinellosis and viral activity.…”