2010
DOI: 10.1016/j.bmc.2010.05.023
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Synthesis and antiplasmodial activity of lycorine derivatives

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Cited by 57 publications
(59 citation statements)
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“…The solvent was evaporated under reduced pressure. The residue was purified by silica gel column chromatography (CHCl 3 -MeOH, 20:1) to yield 8 [18,19] (70 mg, 0.245 mmol).…”
Section: Methodsmentioning
confidence: 99%
“…The solvent was evaporated under reduced pressure. The residue was purified by silica gel column chromatography (CHCl 3 -MeOH, 20:1) to yield 8 [18,19] (70 mg, 0.245 mmol).…”
Section: Methodsmentioning
confidence: 99%
“…Among the Amaryllidaceae alkaloids, galanthamine, is used for the treatment of mild and moderate cases of Alzheimer's disease (AD) (Howes, Perry, 2011). Lycorine, a major alkaloid found in many Amaryllidaceae species, has been shown to have a wide variety of biological activities such as antitumoral , antimalarial (Cedron et al, 2010), hepatoprotective (Ilavenil, Kaleeswaran, Ravikumar, 2012), antiviral (He et al, 2013), antifungal (Shen et al, 2014) and antiparasitic (Giordani et al, 2012) activities. Due to its diverse biological properties, it has been to the interest of phytochemists to determine the content of this alkaloid using various analytical techniques in Amaryllidaceous plants (Abou-Donia et al, 2007;Petruczynik et al, 2016).…”
Section: Introductionmentioning
confidence: 99%
“…In 1956, scientists determined the three-dimensional structure of lycorine by single crystal. Modern pharmacological research shows that lycorine has anti-inflammatory, inhibiting acetylcholinesterase, alkali resistant malaria, cardiovascular protection and a variety of tumor cell apoptosis induced by alkali, lycorine also has broad antiviral activity, such as SARS virus, herpes simplex virus, vaccinia virus, Punta Toro virus and Rift Valley fever virus [2][3][4] . On the other hand, the study of lycorine and its derivatives have also greatly promoted the progress in the treatment of diseases such as cancer, Alzheimer's disease, viral infection and other serious harm to human health [5][6][7] .…”
Section: Introductionmentioning
confidence: 99%