Synthesis and Antiplatelet Activites of Some Derivatives of p-Coumaric Acid

Ekowati, Juni; Diyah, Nuzul Wahyuning; Syahrani, Achmad

doi:10.23939/chcht13.03.296

Cited by 6 publications

(5 citation statements)

References 17 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Based on research conducted by Ekowati et al (2019), the addition of hydroxy and methoxy groups can increase antiplatelet activity. Referring to the study by Ekowati et al (2019) regarding testing the antiplatelet activity of p-coumaric acid derivative compounds, including p-methoxycinnamic acid and phydroxycinnamic acid in a dose of 80 mg with the same method as this study, which produced the same antiplatelet activity compared to acetosal for pmethoxycinnamic compounds and antiplatelet activity of p-hydroxycinnamic acid compound which is lower than acetosal but still has an antiplatelet effect.…”

Section: Discussionmentioning

confidence: 99%

Synthesis and Antiplatelet Activity of 4-Hidroxy-3-Methoxycinnamic Acid

Marentek

Budiati

Ekowati

2022

JFIKI

Self Cite

View full text Add to dashboard Cite

Background: Cinnamic acid and its derivatives have been widely studied for their efficacy because of the pharmacological effect on good health and well being. Microwave irradiation is more time effective to synthesize than conventional heating method because it conducts heat faster and shortens the reaction time. Objective: This study aimed to synthesize 4-hydroxy-3-methoxycinnamic acid using microwave irradiation and its antiplatelet activity by blood clotting time method. Methods: Synthesis of 4-hydroxy-3-methoxycinamic acid with malonic acid and 4-hydroxy-3-methoxybenzalehyde as a starting material using ammonium acetate catalyst with microwave irradiation (960 Watt, 4 minutes). The synthesis results were tested for purity by thin-layer chromatography, a melting point determination and structure identification (UV-Vis, infrared, and proton NMR spectrometry). The antiplatelet activity test consisted of a negative control group CMC-Na, a positive control acetosal, cinnamic acid, and 4-hydroxy-3-methoxycinnamic acid, each group consisted of 3 different doses, namely 0.0037 mmol/Kg (I), 0.0069 mmol/Kg (II) and 0.0139 mmol/Kg (III). Results: Synthesis of 4-hydroxy-3-methoxycinamic acid had a yield percentage of 30.55%. The test results showed that the 4-hydroxy-3-methoxycinnamic acid compound has antiplatelet activity with an ED30 value of 1.3080 mg/Kg BW and antiplatelet activity comparable to acetosal. Conclusion: 4-hydroxy-3-methoxycinamic acid can be synthesized by microwave irradiation and had antiplatelet activity 1.7 fold greater than cinnamic acid.

show abstract

Section: Discussionmentioning

confidence: 99%

Synthesis and Antiplatelet Activity of 4-Hidroxy-3-Methoxycinnamic Acid

Marentek

Budiati

Ekowati

2022

JFIKI

Self Cite

View full text Add to dashboard Cite

show abstract

“…Persentase hasil didapatkan dari persentase perbandingan berat hasil metilasi dengan berat hasil teoritis (549 mg) dan didapat prosentase hasil rata-rata 24% (Tabel 4). Ekowati et al, (2019) yang melakukan metilasi asam pkumarat dan dimetil sulfat menghasilkan metil (E)-3-(4metoksifenil) akrilat. Reaksi antara asam o-kumarat dengan pereaksi dimetil sulfat dalam suasana basa KCO3 dan pelarut aseton juga menghasilkan metilasi baik pada gugus asam karboksilat berubah menjadi ester dan gugus OH-fenolik menjadi eter (Yaqin et al, 2021).…”

Section: Persentase Hasil Reaksiunclassified

Antioxidant Face Cream Formulation of Ethanol Extract from Soursop leaves (Annona muricata L)

Rahman,

Liana,

et al. 2023

bikfar

View full text Add to dashboard Cite

Face cream is a treatment cream used to treat facial skin. One of the natural plant ingredients that can be used as an active substance in cream preparations is soursop leaves (Annona muricata L.) which have antioxidant activity. The purpose of this study was to formulate cream preparations from soursop leaf ethanol extract as well as the antioxidant activity of face cream preparations. Soursop leaves were extracted by maceration using a 96% ethanol solvent. Cream preparations in physical quality evaluation include organoleptic, pH, homogeneity, viscosity, spread power, sticking power, centrifugation, determination of emulsion type, and antioxidant activity test with DPPH method at 𝜆 511,5 nm using UV-Vis spectrophotometry. The results that organoleptic cream preparations had color differences. The pH of FI, FII, and FIII creams had an average yield of 6,0-6,6 and were homogeneous. All creams had a viscosity value of 49950 cPs and scatter power at 5,2-5,7 cm. FI, FII, and FIII creams fixed power test with an average value of 26,5-46,5 and physically stable at centrifugation tests with cream emulsion type of O/W. Based on the antioxidant activity, the facial creams of ethanol extract from soursop leaves of FI (3%), FII (5%), and FIII (7%) had IC50 values of 80,64, 46,06, and 10,91 ppm respectively. So this study concluded that the facial cream of ethanol extract from soursop leaves at FI, FII, and FIII meet the physical stability requirements based on organoleptic, pH, homogeneity, viscosity, scatter power, clinging power, centrifugation, and emulsion type tests. FI cream had strong antioxidant activity (IC50 value of 80,64 ppm), then FII and FIII had very strong antioxidant activity (IC50 value of 46,06 and 10,91 ppm. Keywords: Cream, Formulation, Antioxidant, Ethanol extract, Soursop leaves

show abstract

“…Upon literature review, it was noted that omega-3 fatty acids are known to have anti-platelet effects [47][48][49]. In addition to omega-3 fatty acids, chia seeds have several other phenolic compounds such as Hydroxytyrosol acetate, Danshensu, Ferulic acid, p-Coumaric acid derivative, Rosmarinic acid, and Carnosol, which are demonstrated to have anti-platelet effects in previous studies [50][51][52][53][54][55][56]. Thus, the anti-platelet effect associated with chia seeds was found to be more potent than that observed in omega-3 fatty acid-treated animals.…”

Section: 39±0351 Bbbmentioning

confidence: 99%

Protective Effects of Chia Seeds and Omega-3 Fatty Acid against Cyclophosphamide-Induced Oligospermia in Male Wistar Rats: Potential Risks of Adverse Drug Interaction with Chia Seeds

Vaghela,

Navale,

Patel

et al. 2023

Yale J Biol Med

View full text Add to dashboard Cite

Objectives:The aim of this study was to investigate whether chia (Salvia hispanica) seeds, which are rich in omega-3 fatty acids, amino acids, and vitamins with antioxidant properties, can mitigate the negative effects on male reproductive function caused by cyclophosphamide, a frequently used chemotherapeutic agent. Methods: Male wistar rats are divided into seven groups (n=6). All groups except the normal control (NC) received cyclophosphamide (30mg/kg, i.p.) for the first 5 days. The standard group received clomiphene citrate (0.25 mg/kg, p.o.). Treatment groups T1%, T5%, T10%, and ω-3 received 1%, 5%, and 10% chia seeds in the diet, and 880 mg/kg omega-3 fatty acid (p.o) respectively for 15 days. The effect on the reproductive system was evaluated by analysis of epididymal sperm characteristics, biochemical parameters, and serum testosterone level. Results: Clomiphene citrate improved oligospermia via hormone mediated effect. Chia seeds and omega-3 fatty acid treatment also showed improvement in reproductive parameters including oxidative stress and histological features of the testes. Omega-3 fatty acid treatment was more effective for the prevention of cyclophosphamide toxicity on testes as compared to chia seeds. Nasal bleeding was noted in several animals subjected to chia seed treatment. This occurrence might be attributed to chia seeds' impact on coagulation and/or platelet function, potentially heightened due to chemotherapy associated bone marrow suppression. Conclusions: In our study, chia seeds as well as omega-3 fatty acid treatment were found to be protective against cyclophosphamide-induced reproductive toxicity in rats. However, the adverse effect of hemorrhage associated with drug interaction of chia seeds with cytotoxic chemotherapeutic drugs needs careful attention and further investigation.

show abstract

Synthesis and Antiplatelet Activites of Some Derivatives of p-Coumaric Acid

Cited by 6 publications

References 17 publications

Synthesis and Antiplatelet Activity of 4-Hidroxy-3-Methoxycinnamic Acid

Synthesis and Antiplatelet Activity of 4-Hidroxy-3-Methoxycinnamic Acid

Antioxidant Face Cream Formulation of Ethanol Extract from Soursop leaves (Annona muricata L)

Protective Effects of Chia Seeds and Omega-3 Fatty Acid against Cyclophosphamide-Induced Oligospermia in Male Wistar Rats: Potential Risks of Adverse Drug Interaction with Chia Seeds

Contact Info

Product

Resources

About