Synthesis and antiproliferative evaluation of some novel B-nor-D-homosteroids

Synthesis, Crystal Structure, and Insecticidal Activity of Steroidal N-Piperidone

“…41 Treatment of compound 2 with hydroxylamine hydrochloride in the presence of sodium acetate afforded compound 3, 42 and the key intermediate 4 was prepared via thionyl chloride in dry THF to transform the 17-oxime of the D ring into piperidone. 43 By following a published protocol, the 3β-hydroxyl protecting groups were subsequently removed to obtain the final target products compounds 5, 7, I, and II. 43 The synthesis of a fluorescence marker from compound I-9 is illustrated in Scheme 3.…”

Solubility determination and thermodynamic models for dehydroepiandrosterone acetate in mixed solvents of (ethyl acetate + methanol), (ethyl acetate + ethanol) and (ethyl acetate + isopropanol)

“…(4) and (5) can be employed to estimate the solubility of a solute in a binary solvent mixture at different temperatures. They require knowledge of the solute solubility in a pure solvent at the lowest and highest temperatures in order to compute the model parameters by regression analysis [12].…”

“…It can be used as raw material to produce testosterone, methyl testosterone, estradiol, estriol [1][2][3]. Recently, with the development of pharmaceutical industry, more and more applications for DHEA acetate have been exploited [4][5][6]. Several ways have been proposed to prepare DHEA acetate in the publications [7][8][9][10].…”

Studies on the interaction between 3-biotinylate-6-benzimidazole B-nor-cholesterol analogs and ct-DNA

“…[1][2][3][4] So far, our research group has focused on the synthesis and antitumor activity of B-nor steroids. [5][6][7][8][9][10][11][12][13][14] It was found that some steroid compounds with the B-nor-steroid nuclear structure, a cholesterol branch chain, and a pharmacophore of the aromatic heterocyclic ring at the 6-position on the steroid nucleus exhibited good antitumor activity in vitro. 8 Research into compound-DNA interactions is of great significance for improving drug design.…”