Synthesis and antiproliferative evaluation of ferrocenyl and cymantrenyl triaryl butene on breast cancer cells. Biodistribution study of the corresponding technetium-99m tamoxifen conjugate

Underestimated Potential of Organometallic Rhenium Complexes as Anticancer Agents

“…Tc(CO) 3 Cp moiety was conjugated to atriaryl butane skeleton of tamoxifen via an amide bond. 78 Recently, the Re(CO) 3 core has been conjugated to sulfonamide moieties to target human carbonic anhydrases (hCAs), which have emerged as an interesting target for therapy and diagnosis due to their overexpression induced by hypoxia in cancer cells. [79][80][81] High concentration of carbonic acid resulting from this excessive activity of hCAs leads to a pronounced decrease in extracellular pH (down to ca.…”

Synthesis and biodistribution of 1-[2-(cyclopentadienyltricarbonyltechnetium-99m)-2-oxo-ethoxy-phenyl]-1,2-di- (p-hydroxyphenyl)but-1-ene for tumor imaging

“…The synthesis of the ferrocenyl complex, 1 [29] and the cyclopentadienyltricarbonylmanganese derivative, 3 [39] have been previously published.…”

“…The in vitro stability study was carried out in isolated whole rat blood following the procedure reported in the literature [39][40]44]. Around 93% of the radioactivity was Long circulation time is an important feature for radiopharmaceuticals since a large number of passages through the targeted areas might favor radiotracer accumulation leading to better target/non-target ratios.…”

“…We have now found good conditions for the double ligand transfer reaction involving 1, [ 99m TcO4]and Mn(CO)5Br to produce 2 in 95% yield. For identification of the technetium compound, a manganese or rhenium analog was used for comparison using the HPLC technique [38][39]. Therefore, 1-[4-…”

Current research on anti-breast cancer synthetic compounds

“…1-p-(Ferrocenylcarbonylamino-phenyl)-1,2-di(phydroxyphenyl)-but-1-ene (145) was synthesized and exhibited a signicant antiproliferative activities against MCF-7 and MDA-MB-231 BC cells with 4.53 mM and 1 mM, respectively (Table 6). 129 Zheng et al, 130 (Table 6) on MCF-7 cells line does not arise from antiestrogenicity, but rather proceeds through a cytotoxic pathway.…”