Synthesis and Antiproliferative Evaluation of Spirothiadiazolopyridazine Derivatives

Alkylation and 1,3‐Dipolar Cycloaddition of 6‐Styryl‐4,5‐dihydro‐2H‐pyridazin‐3‐one: Synthesis of Novel N‐Substituted Pyridazinones and Triazolo[4,3‐b]pyridazinones

“…3 Å, 11 1 32 Å, 11 1 Å, and 1 1 2 ∘ ; 1 2 12 Å 3 and D (calc., ) = 1.261 Mg m −3 . A total of 11692 data re�ections were collected over the range of ∘ ⩽ 2 ⩽ ∘ ; of these, 1647 (independent and with I ≥2 (I)) were used in the structural analysis.…”

“…Recently, our research group has reported the synthesis and the antiproliferative activities of new pyridazinone derivatives. Some of these compounds exhibited signi�cant cytotoxicity against human and murine cell lines (A2780, A549, P388, and P815) [10,11]. As a part of our program we focused on pyridazinones with biological activity, and in connection with our interest in the chemistry of annelated pyridazinones [10][11][12], in this paper we report the synthesis of a new series of N-substituted pyridazinones and triazolo [4,3-b]pyridazinones, which were obtained, respectively, by alkylation and 1,3-dipolar cycloaddition of 6-styryl-4,5-dihydro-2H-pyridazin-3-one.…”

Synthesis and <i>in Vitro</i> Cytotoxic Activity of Novel Pyrazole-3,4-dicarboxylates

“…The ethyl hydrazono-α-bromoglyoxylates (2a-g) ( Figure 1) selected to generate the corresponding N-aryl-C-ethoxycarbonylnitrile imines were prepared from the reaction of the adequate diazonium salts with ethyl acetoace-tate, followed by bromination of the resulting azoacetoacetic esters [18]. The nitrile imines were generated in situ by basic treatment of the hydrazono-α-bromoglyoxylates [19,20].…”