A new series of N-aryl-4-oxo-1,4-dihydro-pyridazine-3-carboxylic acids has been synthesized by condensation of aryldiazonium with 4-hydroxy-6-methyl-2-pyrone. Some of these compounds exhibited in-vitro cytotoxic activity with moderate to excellent growth inhibition against the murine P815 mastocytoma cell line. Compound 5b showed an important cytotoxic activity against cell line P815 (IC(50 )= 0.40 microg/mL).

No abstract

Novel pyridazine derivatives are synthesized and tested for their cytotoxic activity on the P815 cell line. Compound (IIId) is identified as the most potent derivative. -(MOJAHIDI, S.; RAKIB*, E. M.; SEKKAK, H.; ABOURICHA, S.; BENCHAT, N.; MOUSSE, H. A.; ZYAD, A.; Arch.

Some new N-substituted pyridazinones and triazolo [4,3-b]pyridazinones were synthesized, respectively, by simple alkylation and 1,3-dipolar cycloaddition of pyridazin-3-one with nitrile imines. e regioselectivity of the reactions was ascertained by 1 H, 13 C NMR spectroscopy and X-ray diffraction of the synthesized compounds.

N-Aryl-C-ethoxycarbonylnitrile imines (3a-g) react with ethyl cyanoacetate 1 in 1,3-dipolar cycloaddition to yield novel pyrazole-3,4-dicarboxylates (4a-g) in moderate yields. The reaction of pyrazole-3,4-dicarboxylates (4a, d) with hydrazine afforded pyrazolo[4,3-d]pyridazine-4,7-diones (5a, d) in good yields. All compounds were fully characterized by spectroscopic methods. Some of the newly synthesized compounds were evaluated for their cytotoxic activity against murine P815 mastocytoma cell line.