Synthesis and antiprotozoan evaluation of new alkyl-linked bis(2-thioxo-[1,3,5]thiadiazinan-3-yl) carboxylic acids

Dithiocarbamate salts: biological activity, preparation, and utility in organic synthesis

“…The obtained compounds were evaluated for their activity in vitro against Trypanosoma cruzi strain CL (clone CL B5) and Trichomonas vaginalis strain JH 31A (55). Similarly, 3,5-disubstituted thiadiazine thiones 56 were synthesized by cyclocondensation of alkanedithiocarbamates with formaldehyde and primary amines or amino acids.…”

Thiadiazine Derivatives as Antiprotozoal New Drugs

“…In the first step the diamine reacts with carbon disulfide 2 in the presence of potassium hydroxide 3 to obtain the expected bisdithiocarbamate salt 11 . The addition of formaldehyde 5 and the corresponding amine or aminoacid ( 6 ) to 11 resulted in the cyclocondensation in a slightly alkaline medium (phosphate buffer, pH 7-8) to generate, after treatment with HCl 15%, the desired bis-THTT ( Scheme 3 ) [19-21]. …”

“…Specifically with antiprotozoal activities three series of bis-THTT had been reported [21, 22, 34]. The in vitro activity of compounds belonging to series VIII and IXI (Fig.…”

Synthesis and Cytotoxicity of Bis‐1,3,4‐oxadiazoles and Bis‐pyrazoles Derived from 1,4‐Bis[5‐thio‐4‐substituted‐1,2,4‐triazol‐3‐Yl]‐butane and Their DNA Binding Studies

“…The broad spectrum antifungal agent fluconazole is a bis-triazole derivative. The bis heterocyclic molecules have also shown to exhibit several diverse pharmacological activity such as antimicrobial [3], anti-protozoal [4], anti-inflammatory [5], anti-HIV [6], and cytotoxicity [7][8][9][10][11][12].…”