Synthesis and Antiradical Activity of 2-Arylidenemalonic Acid Dianilides

Abstract

The most common cinnamoyl anilines are avenanthramides, which are natural antioxidants found in oats. This is a rather uncommon and not well-investigated group of antioxidants. This paper deals with 2-arylidenemalonic acid dianilides – cinnamoyl anilines which are decorated with an additional arylaminocarbonyl moiety at α-position of double bond. The DPPH scavenging activity of the title compounds is slightly lower in comparison to the corresponding cinnamoyl anilines. On the other hand, the title dianilides are more active than cinnamic acid anilides containing an additional carboxylic group in the α-position of double bond.

Antiradical and Antioxidant Activity of Compounds Containing 1,3-Dicarbonyl Moiety: An Overview

“…However, the compound most likely acts as a phenol-type antioxidant in this case. Like the curcumin compounds, the lack of α-protons appears to suppress compounds 26 from acting as 1,3-dicarbonyl-type antioxidants [159].…”