Synthesis and antituberculosis activity of new thiazolylhydrazone derivatives

Synthesis and pharmacological evaluation of a novel series of 3-aryl-2-(2-substituted-4-methylthiazole-5-yl)thiazolidin-4-one as possible anti-inflammatory and antimicrobial agents

“…[1][2][3][4][5][6][7][8][9][10][11] Thiazolidinones in particular have been investigated in great detail because of its biological importance. 12 Thiazolidinone nucleus containing compounds shows anti-inflammatory, 13-20 anticonvulsant, [21][22][23][24] hypnotic, 25-27 antitubercular, [25][26][27] antibacterial, antifungal and anticancer [28][29][30][31][32][33][34][35] activities.…”

Antitubercular Drugs Development: Recent Advances in Selected Therapeutic Targets and Rational Drug Design

“…An example is diflunisal, a hydrazide/hydrazone derivative, which has dual effect acting with antimicrobial/anti-inflammatory properties. Furthermore, in thiazolylhydrazone derivatives, SAR studies have found that substitutions on the phenyl ring affect anti-TB activity (45, figure 14) (Turan-Zitouni et al, 2008). Another example of a thiazolylhydrazine is compound 46 (figure 14), which has high anti-TB activity with a IC50 of 6.22 µg/mL and low toxicity (CC50> 40 µg/mL).…”

Tuberculosis: Still a Way to go ahead for a Lead- A Review

“…Thiazolylhydrazone derivatives (Figure 4b): All the synthesized compounds of the series was highly potent with the ability of more than 90% hindrance to the growth of the bacilli along with least or none cytotoxicity has been reported within the range of MIC (MIC > 6.25µg/ml) [59].…”