Synthesis and pharmacological evaluation of a novel series of 3-aryl-2-(2-substituted-4-methylthiazole-5-yl)thiazolidin-4-one as possible anti-inflammatory and antimicrobial agents

Discovery and Characterization of Potent Thiazoles versus Methicillin- and Vancomycin-Resistant Staphylococcus aureus

“…9, 10 In this study, whole-cell screening assays of libraries of substituted thiazoles and thiadiazoles identified a novel lead compound that displayed notable antibacterial activity against MRSA. The lead compound 1a (Figure 1) consists of a thiazole central ring connected to two unique structural features – a cationic element at the C5-position and a lipophilic moiety at the C2-position.…”

A retrospect on antimicrobial potential of thiazole scaffold

“…By the condensation of thioglycolic acid in toluene, 2‐aryl/benzyl‐4‐methylthiazole‐5‐carbaldehyde and aromatic amines, series of 3‐aryl‐2‐(2‐aryl/benzyl‐4‐methylthiazole‐5‐yl)thiazolidin‐4‐one was developed by Bobade and coworkers . in vitro antimicrobial activity screening of the derivatives was done against E. coli , St. aureus , C. albicans and A. niger .…”

Synthesis and Antimicrobial Screening of 2‐Aryl‐5‐((2‐arylthiazol‐4‐yl)methyl)‐1,3,4‐oxadiazole Derivatives

“…Thiazole is an important pharmacophore, and its coupling with other rings could furnish new biologically active compounds . Thiazole compounds have exhibited a broad range of biological activities such as antitumor , anticancer , antibiotic , anti‐inflammatory , antibacterial and antifungal , antitubercular , antiviral , antidepressant activity , Peroxisome proliferator‐activated receptor (PPAR) α/γ/δ pan agonists , and antihelmintic activities. The heterocyclic compounds containing 1,3,4‐oxadiazole nuclei showed anti‐inflammatory , hypoglycemic , anti‐HIV , antitumor , antibacterial , antifungal , antihypertensive , antituberculosis , analgesic , anticonvulsant , and herbicidal activities.…”