Synthesis and antitumor activity of new thiosemicarbazones of salicylaldehyde and 4-diethylaminobenzaldehyde

Dilanyan, E. R.; Ovsepyan, T. R.; Arsenyan, F. G.; Garibdzhanyan, B. T.

doi:10.1007/bf02223741

Cited by 3 publications

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“…for chelates 5, 6, and 7, respectively, corresponding to one unpaired electron. The absorption spectra of Cu(II) chelates are consistent with the earlier report of square planer chelates [46] and show a low intense d-d band in the range 600-650 nm corresponding to 2…”

Section: T a B L Esupporting

confidence: 89%

“…During the past five decades, there have been much development of research in the coordination chemistry of nitrogen–oxygen–sulfur donor ligands such as substituted thiosemicarbazides, thiosemicarbazones, and dithiocarbazates. Thiosemicarbazones, especially aromatic and heteroaromatic componds, have been used in several applications as depending on the ligand donor atoms, their flexibility and capability to coordinate either in neutral or deprotonated form, [ 1 ] they can be used as antitumor agents, [ 2 ] anticonvulsants [ 3 ] and herbicides. [ 4 ] It was found that 2‐hydroxy‐1‐naphthaldehyde thiosemicarbazone and its derivatives can be used as selective agents with cholesterol, glucose, and uric and amino acids in fluorometric determinations, in addition to Fe(II) and Cu(II) in spectrophotometric techniques.…”

Section: Introductionmentioning

confidence: 99%

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Synthesis, spectroscopic, electrochemical characterization, density functional theory (DFT), time dependent density functional theory (TD‐DFT), and antibacterial studies of some Co(II), Ni(II), and Cu(II) chelates of (E)‐4‐(1,5‐dimethyl‐3‐oxo‐2‐phenyl‐2,3‐dihydro‐1H‐pyrazol‐4‐yl)‐1‐(3‐hydroxynaphthalen‐2‐yl)methylene) thiosemicarbazide Schiff base ligand

El‐Sawaf

Abdel‐Monem

Azzam

2020

Applied Organom Chemis

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In this study, mononuclear Co(II), Ni(II), and Cu(II) chelates of the potentially tridentate O, N, S donor ligand (E)-4-(1,5-dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazol-4-yl)-1-(3-hydroxynaphthalen-2-yl)methylene) thiosemicarbazide (H 2 L) were synthesized and characterized by elemental analyses, conductivity measurements, Fourier transform infrared spectroscopy, UV-visible spectroscopy, magnetic susceptibility, electron spin resonance (ESR) spectral analysis, thermal thermogravimetric analyses, cyclic voltammetry, and theoretical density functional theory (DFT) and time dependent density functional theory (TD-DFT) studies. The potential donors O (phenolic) and N (azomethine) are found in a syn configuration due to a strong intramolecular hydrogen bond [O-H …. N(1)] as shown in the 1 H NMR spectrum of the free ligand. In addition, analytical results revealed the formation of the metal chelates in a ligand-to-metal molar ratio of 1:1. The organic ligand (H 2 L) coordinated to the metal center through azomethine nitrogen, phenolate oxygen, and thione/thiolate sulfur groups with the formation of a five-and six-membered rings. The magnetic and spectral results supported the formation of tetrahedral geometry around the Co(II) and Ni(II) centers, while Cu(II) centers were assumed to have a square planar geometry. The time dependent density functional theory (TD-DFT) calculation outputs were used to expect and explain the experimental bathochromic and hypsochromic shifts resulting from the ligand chelation. The antibacterial activity of the compounds under study was evaluated in vitro against Staphylococcus aureus and Escherichia coli demonstrating Gram-positive and Gram-negative bacteria, respectively. It was found that among synthesized compounds, Cu(II) chelate 5 showed the most inhibitory activity against both Gram-positive and Gram-negative

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Section: T a B L Esupporting

confidence: 89%

Section: Introductionmentioning

confidence: 99%

Synthesis, spectroscopic, electrochemical characterization, density functional theory (DFT), time dependent density functional theory (TD‐DFT), and antibacterial studies of some Co(II), Ni(II), and Cu(II) chelates of (E)‐4‐(1,5‐dimethyl‐3‐oxo‐2‐phenyl‐2,3‐dihydro‐1H‐pyrazol‐4‐yl)‐1‐(3‐hydroxynaphthalen‐2‐yl)methylene) thiosemicarbazide Schiff base ligand

El‐Sawaf

Abdel‐Monem

Azzam

2020

Applied Organom Chemis

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ChemInform Abstract: Synthesis and Antitumor Activity of New Thiosemicarbazones of Salicylic Aldehyde and 4‐Diethylaminobenzaldehyde

et al. 1997

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A Nickel(II) N′-(2-hydroxybenzylidene)morpholine-4-carbothiohydrazide Electrocatalyst for Hydrogen Evolution Reaction

Abdulaziz¹

2022

International Journal of Electrochemical Science

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In this study, a nickel(II) N′-(2-hydroxybenzylidene)morpholine-4-carbothiohydrazide complex has been evaluated as an electrocatalyst for the hydrogen evolution reaction (HER) in the presence of 0.2 M [NBu4][BF4], and deaerated DMF. The cyclic voltammetry shows two reduction peaks at -0.95 V and -1.34 V corresponding to the reduction of the couples Ni 2+ /Ni +1 and Ni 1+ /Ni respectively and the two oxidation peaks appeared at 0.68 V and 1.04 V. Additionally, the hydrogen evolution reaction was investigated using a known concentration of acetic acid. The second reduction peak was shifted to approximately 57 V relative to the free acetic acid reduction peak. The maximum activity was recorded in the presence of 31.5 equivalents of acetic acid and reached the current saturation at 235 µA.

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Synthesis and antitumor activity of new thiosemicarbazones of salicylaldehyde and 4-diethylaminobenzaldehyde

Cited by 3 publications

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ChemInform Abstract: Synthesis and Antitumor Activity of New Thiosemicarbazones of Salicylic Aldehyde and 4‐Diethylaminobenzaldehyde

A Nickel(II) N′-(2-hydroxybenzylidene)morpholine-4-carbothiohydrazide Electrocatalyst for Hydrogen Evolution Reaction

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