Synthesis and antitumor activity of cyclopentadienyltitanium substituted polyoxotungstate [CoW11O39(CpTi)]7− (Cp=η5-C5H5)

Wang, Xiaohong; Liu, Jingfu; Li, Jianxin; Yang, Yong; Liu, Jutao; Li, Bin; Pope, Michael T.

doi:10.1016/s0162-0134(02)00631-1

Cited by 86 publications

(49 citation statements)

References 6 publications

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“…This desired POM was synthesized using the [8]. Successful synthesis of CoW11CpTi was confirmed by comparing the FT-IR spectra of the same POM originally synthesized by Wang et al [8].…”

Section: Discussionmentioning

confidence: 92%

“…In other words, for 98% of POM to escape from the matrix of nanocomposites requires 11 hrs. This is greatly significant for drug development as POMs at high dosages are lethal of the cells of the body, so its sustained release is inevitable [8]. This can be seen when the cytotoxicity of bare CoW 11 CpTi and CoW 11 CpTi -CSYC100 nanocomposite was tested in vitro on normal myoblast cell lines C2C12 and A549 lung cancer cell line using MTT assay.…”

Section: Discussionmentioning

confidence: 99%

“…Results on normal myoblast cell lines C2C12 are essentially important because it mimics the behavior of normal healthy cells of the body. It was observed that CoW 11 CpTi-CSYC100 nanocomposite was comparatively less toxic than bare CoW 11 CpTi; this can be due to the phenomena of sustain release of CoW 11 CpTi from the CSYC100 nanocomposites [6,8,10,13]. Despite such positive results, extensive research is still needed to be done on model organisms to make highly specific and finely tuned POM baring nanocomposites as a futuristic medicine.…”

Section: Discussionmentioning

confidence: 99%

“…It is reported that polyoxotungstate CoW 11 CpTi curiously decreased tumor weight of the rats bearing HLC (colon cancer cell), HL-60 (leukemia), and SSMC-7721 (liver cancer cell) where the experimental results were procured using the animal tumor implantation method. The in vivo anticancer efficacy of CoW 11 CpTi is at par with the clinical anticancer drugs 5-fluorouracil and CP (abbreviation of cyclophosphamide), but the cytotoxicity of CoW 11 CpTi is reported to be less than them [8].…”

Section: Introductionmentioning

confidence: 99%

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FABRICATION OF NOVEL ANTICANCER POLYOXOMETALATE [CoW11O39(CpTi)]7- -CHITOSAN NANO-COMPOSITE, ITS TOXICITY REDUCTION AND SUSTAINED RELEASE

Pandya

Joshi

2017

Asian J Pharm Clin Res

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Objectives: Polyoxometalates (POMs) are proved to be important for applications in medicine and in material science. Here, we represent nanocomposite formation of tungsten-containing potent anticancer polyanion, K 6 H [CoW 11 O 39 (CpTi)].13H 2 O (CoW 11 CpTi) with biocompatible ChitosanYC-100 (CSYC100) with the goal to reduce its heavy metal toxicity. Methods:Synthesis of "POM-CSYC100 nanocomposite" was attained without the aid of any cross-linker through electrostatic interaction technique. Nanocomposites were characterized using Fourier transform infrared spectroscopy, dynamic light scattering, transmission electron microscopy, and thermogravimetric analysis. The release profile recorded was slow and sustained at physiological pH. In vitro cytotoxicity assays which show an attribute to reduce the toxicity of these POM were performed on C2C12 (mouse myoblast cell line) and A-549 (lung cancer cell line), which proved the reduced toxicity of nanocomposites as compared to the bare drugs.Results: Sustained release studies showed there was a slow and steady release of CoW 11 CpTi for 11 hrs, with the 98% of collective release at the end. From in vitro cytotoxic assay, it was deduced that CoW 11 CpTi -CSYC100 nanocomposite at the concentrations of 1.25 mM, and lower did not exhibit toxic effect on C2C12 cells as 95% total C2C12 cell mass remained viable. While in the case of A549 cells highest 5 mM concentration of bare CoW 11 CpTi is toxic to the cancer cells and after encapsulation cell viability increases from 10% to 55%. Conclusion:Thus, this study has designated the probability of using POM-chitosan nanocomposite for less toxic and effective biomedicinal applications.

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“…This desired POM was synthesized using the [8]. Successful synthesis of CoW11CpTi was confirmed by comparing the FT-IR spectra of the same POM originally synthesized by Wang et al [8].…”

Section: Discussionmentioning

confidence: 92%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

FABRICATION OF NOVEL ANTICANCER POLYOXOMETALATE [CoW11O39(CpTi)]7- -CHITOSAN NANO-COMPOSITE, ITS TOXICITY REDUCTION AND SUSTAINED RELEASE

Pandya

Joshi

2017

Asian J Pharm Clin Res

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“…[7] Tuning of POM properties can influence the recognition and reactivity of these structures towards biological macromolecules, which so far has led to the discovery of three kinds of potential therapeutic applications. The first type of activity covers the field of viral infections, [8] a second type is related to their use as antitumor agents [9] and the third type of activity is found in the area of bacterial infections. [10] The biological activity of POMs has been studied extensively and either their redox activity [11] or their interaction with biomolecules [7,12] has been proposed as the basic mechanism of their biological action.…”

Section: Introductionmentioning

confidence: 99%

Molecular Origin of the Hydrolytic Activity and Fixed Regioselectivity of a Zr^IV‐Substituted Polyoxotungstate as Artificial Protease

Stroobants¹,

Goovaerts²,

Absillis³

et al. 2014

Chemistry A European J

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A multitechnique approach has been applied in order to identify the thermodynamic and kinetic parameters related to the regioselective hydrolysis of human serum albumin (HSA) or Cys392ÀGlu393 peptide bonds. This is in agreement with the interaction studies as the Arg114ÀLeu115 peptide bond is located in the positive cleft of HSA and the three remaining peptide bonds are each located near an upstream acidic residue, which can be expected to coordinate to the metal ion. A detailed kinetic study has evidenced the formation of additional fragments upon prolonged reaction times. Edman degradation of the additional reaction products has shown that these fragments result from further hydrolysis at the initially observed cleavage positions, indicating a fixed selectivity for K 15 H[Zr(a 2 -P 2 W 17 O 61 ) 2 ].

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The Synthesis and Biological Function of a Novel Sandwich‐Type Complex Based on {SbW₉} and Flexible bpp Ligand

Wang

et al. 2019

Adv Healthcare Materials

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A novel sandwich‐type complex [Na(H2O)4][{Na3(H2O)5}{Mn3(bpp)3} (SbW9O33)2}]·8H3O (MnSbW‐bpp) (bpp = 1,3‐bis(4‐pyridyl) propane) is synthesized and characterized by elemental analysis, IR, thermogravimetric analysis, and single‐crystal X‐ray diffraction. The MnSbW‐bpp compound is the first sandwich case bridged by a flexible ligand. Its biological function of MnSbW‐bpp in antitumor activity is also determined in vitro and in vivo. The inhibitory proliferation and induction of apoptosis are performed by flow cytometry assay, S180 (sarcoma) tumor xenograft in ICR mice, the color Doppler ultrasound monitor, and TdT‐mediated dUTP‐biotin nick end labeling assay. The results show that the novel compound—MnSbW‐bpp—is synthesized and identified by its physical and chemical characteristics, such as the fluorescent and paramagnetic activities. MnSbW‐bpp indicates a potency inhibition of human cancer lines, such as SGC‐7901, HT‐29, HepG2, Hela, U2OS, SaoS2, and HMC cells. MnSbW‐bpp also inhibits the growth of tumor xenograft in mice, induced cell apoptosis, and released cytochrome c in vivo and in vitro. Thus, MnSbW‐bpp, as a new compound, possesses the potent inhibition of cancer cells, which indicates that the MnSbW‐bpp has potential merit for the further evaluation of a novel antitumor agent.

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Synthesis and antitumor activity of cyclopentadienyltitanium substituted polyoxotungstate [CoW11O39(CpTi)]7− (Cp=η5-C5H5)

Cited by 86 publications

References 6 publications

FABRICATION OF NOVEL ANTICANCER POLYOXOMETALATE [CoW11O39(CpTi)]7- -CHITOSAN NANO-COMPOSITE, ITS TOXICITY REDUCTION AND SUSTAINED RELEASE

FABRICATION OF NOVEL ANTICANCER POLYOXOMETALATE [CoW11O39(CpTi)]7- -CHITOSAN NANO-COMPOSITE, ITS TOXICITY REDUCTION AND SUSTAINED RELEASE

Molecular Origin of the Hydrolytic Activity and Fixed Regioselectivity of a Zr^IV‐Substituted Polyoxotungstate as Artificial Protease

The Synthesis and Biological Function of a Novel Sandwich‐Type Complex Based on {SbW₉} and Flexible bpp Ligand

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Synthesis and antitumor activity of cyclopentadienyltitanium substituted polyoxotungstate [CoW11O39(CpTi)]7− (Cp=η5-C5H5)

Cited by 86 publications

References 6 publications

FABRICATION OF NOVEL ANTICANCER POLYOXOMETALATE [CoW11O39(CpTi)]7- -CHITOSAN NANO-COMPOSITE, ITS TOXICITY REDUCTION AND SUSTAINED RELEASE

FABRICATION OF NOVEL ANTICANCER POLYOXOMETALATE [CoW11O39(CpTi)]7- -CHITOSAN NANO-COMPOSITE, ITS TOXICITY REDUCTION AND SUSTAINED RELEASE

Molecular Origin of the Hydrolytic Activity and Fixed Regioselectivity of a ZrIV‐Substituted Polyoxotungstate as Artificial Protease

The Synthesis and Biological Function of a Novel Sandwich‐Type Complex Based on {SbW9} and Flexible bpp Ligand

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Molecular Origin of the Hydrolytic Activity and Fixed Regioselectivity of a Zr^IV‐Substituted Polyoxotungstate as Artificial Protease

The Synthesis and Biological Function of a Novel Sandwich‐Type Complex Based on {SbW₉} and Flexible bpp Ligand