Synthesis and antitumor activity of 5-methylbenzofuryl-substituted 1,2,4-triazoles and triazoline-5-thiones

Kaldrikyan, M. A.; Melik-Oganjanyan, Rafael G.; Aresnyan, F. H.

doi:10.1007/s11094-013-0924-3

Cited by 7 publications

(1 citation statement)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…On the other hand, sulfur-linked 1,2,4-triazoles represent an important group of sulfur compounds that are promising for use in lead compound discovery, especially thione-substituted 1,2,4-triazole ring. Thus far, many bioactive sulfur-linked 1,2,4-triazole have been reported, such as antibacterial activity [ 22 , 23 ], antitumor activity [ 24 ], anti-HIV activity [ 25 ], anti-TMV (tobacco mosaic virus) activity [ 26 ], and so on.…”

Section: Introductionmentioning

confidence: 99%

Microwave Assistant Synthesis, Antifungal Activity and DFT Theoretical Study of Some Novel 1,2,4-Triazole Derivatives Containing Pyridine Moiety

Sun

Yang

Shi

et al. 2014

IJMS

View full text Add to dashboard Cite

In order to investigate the biological activity of novel 1,2,4-triazole compounds, seventeen novel 1,2,4-triazole derivatives containing pyridine moiety were synthesized under microwave assistant condition by multi-step reactions. The structures were characterized by 1H NMR, MS and elemental analyses. The target compounds were evaluated for their fungicidal activities against Stemphylium lycopersici (Enjoji) Yamamoto, Fusarium oxysporum. sp. cucumebrium, and Botrytis cinerea in vivo, and the results indicated that some of the title compounds displayed excellent fungicidal activities. Theoretical calculation of the title compound was carried out with B3LYP/6-31G (d,p). The full geometry optimization was carried out using 6-31G (d,p) basis set, and the frontier orbital energy, atomic net charges were discussed, and the structure-activity relationship was also studied.

show abstract