Three‐component synthesis of 5‐substituted 6‐acetyl‐2‐amino‐7‐methyl‐5,8‐dihydropyrido[2,3‐d]pyrimidines was brought to facile energy‐efficient and environmental‐friendly conditions using multicomponent reaction, microwave field as an activation method and hot water as a solvent. A series of the target compounds was synthesized using the developed procedure.
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