Synthesis and Antiviral Activities of New Pyrazolo[4,3‐c]quinolin‐3‐ones and Their Ribonucleoside Derivatives.

Abstract

Synthesis and Antiviral Activities of New Pyrazolo[4,3-c]quinolin-3-ones andTheir Ribonucleoside Derivatives. -Several ribonucleoside derivatives of type (VI) and the corresponding heterocyclic bases (III) are synthesized and evaluated against vaccinia virus (VV) and herpes simplex virus type 1 (HSV-1). Derivatives (IIIa) and (IIIb) show modest inhibitory activity against VV. All compounds (III) show a modest inhibition of HSV-1. -(DE OLIVEIRA, M. R. P.; ALVES, T. R.; PINTO, A. C.; PEREIRA, H. D. S.; LEAO-FERREIRA, L. R.; MOUSSATCHE, N.; FRUGULHETTI, I. C. D. P. P.; FERREIRA, V. F.; DE SOUZA*, M. C. B. V.; Nucleosides, Nucleotides Nucleic Acids 23 (2004) 5, 735-748; Dep. Quim. Org., Inst. Quim., Univ. Fed. Rio de Janeiro,

Effect of Oral Treatment with Pyrazole Carbohydrazide Derivatives against Murine Infection by Leishmania amazonensis

“…26 However, other studies showed that footpad thickness does not always reflect parasite burden and may be influenced by leukocyte infiltration at the infection site. 27,28 The anti-inflammatory effects on evolution of skin lesions and anti-Leishmania activity of pyrazole carbohydrazide derivatives should be investigated.…”