No abstract

Several new pyrazolo[4,3-c]quinolin-3-one ribonucleosides (5a-g) and their corresponding heterocycle moieties (3a-g) were synthesized and evaluated against vaccinia virus (VV) and herpes simplex virus type 1 (HSV-1). The derivatives 3c and 3d showed modest inhibitory activity against vaccinia virus reaching 70% at a concentration of 100 microM. All heterocyclic compounds (3a-f) showed a modest inhibition against HSV-1, reaching the maximal inhibitory effect around 20-30%. The antiviral effects of most of the pyrazolo[4,3-c]quinolin-3-one ribonucleosides (5a-f) on VV and HSV were not impressive.

A series of new ribonucleosides 1a–d having 4‐oxoquinoline‐3‐carboxylic acid substituted with a chloro or bromo atom in the aromatic ring, as the nitrogen base, was synthesized and examined for anti‐HIV activity. Compounds 1a and 1c showed a modest inhibition activity on HIV‐1 reverse transcriptase, inhibiting 10% of the enzyme activity at the concentration of 100 μM. © 1999 John Wiley & Sons, Inc. Heteroatom Chem 10: 197–202, 1999

No abstract

Abstracts,4-Dihydropyrimidin-2(lH)-ones were synthesized in good yields by solvent-free one-pot three-component Biginelli condensation in the presence of molten tetrabutylammonium bromide or ammonium bromide as catalyst,irrespective of the presence of electron donating or electron withdrawing groups aromatic aldehydes.In the recent past, tetrabuthylammonium bromide (TBAB) is emerging as an effetive phase transfer catalyst for various organic reactions. We sought to explore the possibilty of TBAB as catalyst for Biginelli reaction. In this paper, we describe a '