Synthesis and antiviral activity of hydrophosphorylated inosines

Belakhov, V. V.; Levina, A. A.; Shenin, Yu. D.; Ионин, Б. И.; Shtil'bans, E. B.; Rachkovskaya, L. A.; Chekunova, E. V.; Маренникова, С. С.; Shneider, M. A.

doi:10.1007/bf00767031

Pharm Chem J

1990

DOI: 10.1007/bf00767031

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Synthesis and antiviral activity of hydrophosphorylated inosines

V. V. Belakhov

A. A. Levina

Yu. D. Shenin

et al.

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Cited by 2 publications

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“…A more interesting direction is related to the search for semisynthetic derivatives [10 -15]. Previously, we obtained aminophenylphosphonic derivatives of levorin [16].…”

mentioning

confidence: 99%

Synthesis and antifungal activity of organofluorine derivatives of levorin

Belakhov

Shenin

Araviisky³

2007

Pharm Chem J

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Reactions of the polyene macrolide antibiotic levorin with organofluorine alcohols lead to the formation of organofluorine esters. Two organofluorine derivatives of levorin have been synthesized and their physicochemical and biological properties have been studied. These derivatives show high antifungal activity against a large number of test cultures. The acute toxicity (LD 50 ) of levorin derivatives was about half that of the initial antibiotic. 480 0091-150X/07/4109-0480

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“…A more interesting direction is related to the search for semisynthetic derivatives [10 -15]. Previously, we obtained aminophenylphosphonic derivatives of levorin [16].…”

mentioning

confidence: 99%

Synthesis and antifungal activity of organofluorine derivatives of levorin

Belakhov

Shenin

Araviisky³

2007

Pharm Chem J

Self Cite

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Polyfunctional Drugs: Search, Development, Use in Medical Practice, and Environmental Aspects of Preparation and Application (A Review)

Belakhov

2022

Russ J Gen Chem

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Synthesis and antiviral activity of hydrophosphorylated inosines

Cited by 2 publications

References 5 publications

Synthesis and antifungal activity of organofluorine derivatives of levorin

Synthesis and antifungal activity of organofluorine derivatives of levorin

Polyfunctional Drugs: Search, Development, Use in Medical Practice, and Environmental Aspects of Preparation and Application (A Review)

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