Synthesis and antiviral evaluation of 2-amino-6-carbamoylpurine dioxolane nucleoside derivatives and their phosphoramidates prodrugs

Cho, Jong Hyun; Bondana, Lavanya; Detorio, Mervi; Montero, Cathy; Bassit, Leda; Amblard, Franck; Coats, Steven J.; Schinazi, Raymond F.

doi:10.1016/j.bmc.2014.10.003

Cited by 4 publications

(2 citation statements)

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“…In addition, compounds that exhibited inhibition toward histoned eacetylation also showedc orrelated cytotoxicity against three human cancer cell lines. [94] In the same year,C orrado et al reported 1,4-dioxolanetriazaspirodecanone derivativesa sn ociceptin/orphanin FQ receptor ligands. They reported the synthesis of sigma receptor ligands by combining different substituted five-membered heterocyclic rings with appropriate amines.…”

Section: Pharmacological Profile Of Furan Derivativesmentioning

confidence: 99%

“…They also assessed the synthesised molecules for their ability to block HIV and HBV replication, along with their cytotoxicity towardv arious human cell lines. [94] In the same year,C orrado et al reported 1,4-dioxolanetriazaspirodecanone derivativesa sn ociceptin/orphanin FQ receptor ligands. They selected spiropiperidine core to synthesise as eries of N-substituted analogues.F urther the synthesised compounds were evaluated for their nociceptino pioid peptide (NOP) receptor agonist potency.…”

Section: Pharmacological Profile Of Dioxolane Derivativesmentioning

confidence: 99%

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The Current Status of O‐Heterocycles: A Synthetic and Medicinal Overview

Singh

Silakari

2018

ChemMedChem

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O-Heterocycles have been explored in the field of medicinal chemistry for a long time, but their significance has not been duly recognised and they are often shunned in favour of N-heterocycles. The design of bioactive molecules for nearly every pathophysiological condition is primarily focused on novel N-heterocycles. The main reasons for such bias include the ease of synthesis and possible mimicking of physiological molecules by N-heterocycles. But considering only this criterion rarely provides breakthrough molecules for a given disease condition, and instead the risks of toxicity or side effects are increased with such molecules. On the other hand, owing to improved synthetic feasibility, O-heterocycles have established themselves as equally potent lead molecules for a wide range of pathophysiological conditions. In the last decade there have been hundreds of reports validating the fact that equally potent molecules can be designed and developed by using O-heterocycles, and these are also expected to have comparably low toxicity. Even so, researchers tend to remain biased toward the use of N-heterocycles over O-heterocycles. Thus, this review provides a critical analysis of the synthesis and medicinal attributes of O-heterocycles, such as pyrones, oxazolones, furanones, oxetanes, oxazolidinones, and dioxolonones, and others, reported in the last five years, underlining the need for and the advantages guiding researchers toward them.

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Section: Pharmacological Profile Of Furan Derivativesmentioning

confidence: 99%

Section: Pharmacological Profile Of Dioxolane Derivativesmentioning

confidence: 99%