Synthesis and Antiviral Evaluation of Novel Cyclopropyl Nucleosides, Phosphonate Nucleosides and Phosphonic Acid Nucleosides.

Abstract

Nucleic acids U 0700Synthesis and Antiviral Evaluation of Novel Cyclopropyl Nucleosides, Phosphonate Nucleosides and Phosphonic Acid Nucleosides. -Novel phenyl-branched cyclopropyl nucleosides [cf. (VII)] as well as related phosphonate and phosphonic acid nucleosides [cf. (X)] are synthesized and evaluated for their antiviral effects. None of the products exhibit good antiviral activity. Compound (Xb) possesses moderate anti-HCMV activity. -(OH, C. H.; HONG*, J. H.; Arch. Pharm. (Weinheim, Ger.) 339 (2006) 9, 507-512; Coll. Pharm., Chosun Univ., Gwangju 501-759, S. Korea; Eng.) -R. Langenstrassen 52-210