Synthesis and Antiviral Evaluation of Some 5‐N‐Arylaminomethyl‐2‐glycosylsulphanyl‐1,3,4‐oxadiazoles and Their Analogs against Hepatitis A and Herpes Simplex Viruses

Synthesis and antiviral activity of new substituted pyrimidine glycosides

“…Moreover, the 5-substituted derivatives of pyrimidine acyclonucleoside analogs have exhibited pronounced inhibitory properties with respect to uridine phosphorylase and have enhanced antitumor action [24]. Owing to the above significance and our interest in the synthesis of new and potent antiviral nucleoside analogs [32][33][34], herein we report the synthesis and anti HBV activity of new substituted pyrimidine acyclic nucleosides.…”

Synthesis and Antimicrobial Activity of New 2,5‐Disubstituted 1,3,4‐Oxadiazoles and 1,2,4‐Triazoles and Their Sugar Derivatives

“…[31][32][33][34][35] Oxadiazole and triazole ring systems have been reported to be synthesized either by cyclization of acyclic diacylhydrazines or ring conversion. [36] In view of the above facts and as continuation of interest in identification of new valuable candidates in designing new, potent and less toxic antimicrobial agents, [35,[37][38][39][40][41] we here report the synthesis and antimicrobial activity of new 2,5-disubstituted 1,3,4-oxadiazoles and 1,2,4triazoles as well as their derived acyclic C-nucleoside analogs incorporating both ring systems.…”

Synthesis and antimicrobial activity of new 1-[(tetrazol-5-yl)methyl] indole derivatives, their 1,2,4-triazole thioglycosides and acyclic analogs

“…1) have been shown to possess potential antimicrobial activity (Khalil, 2006(Khalil, , 2007. The above facts and our interest (El-Sayed et al, 2008a, 2008b, 2009a, 2009b, 2009c in novel biologically active leads by means of attaching of carbohydrate moieties to newly synthesized heterocycles promoted us to synthesize new substituted tetrazole glycosides, their acyclic analogs and 1,2,4-triazoles thioglycosides, and to evaluate their antimicrobial activity. Furthermore, it was of interest to determine the influence of attachment of sugar moieties to the synthesized tetrazole and substituted 1,2, 4-triazole derivatives on their antimicrobial activity.…”