Synthesis and antimicrobial activity of new 1-[(tetrazol-5-yl)methyl] indole derivatives, their 1,2,4-triazole thioglycosides and acyclic analogs

El-Sayed, Weal A.; Megeid, Randa E. Abdel; Abbas, Hebat‐Allah S.

doi:10.1007/s12272-011-0706-y

Cited by 36 publications

(14 citation statements)

References 38 publications

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“…12 Pharmacologically, because of the effect of gram-negative or gram-positive bacteria on the health of human, thus some potential drugs/products must be synthesized. 13,14 Tetrazole contains compounds reported to possess diverse chemotherapeutic activities as antibacterial, 15 and antifungal. 16 Example of one of tetrazole derivatives is the product from the reaction between imine compound (N,N'-([1,1'-biphenyl]-4,4'-diyl) bis (1-(pyridine -4 -yl) methanimine)) and sodium azide (Scheme 4).…”

Section: Scheme 3 Structure Of Tetrazole Ringmentioning

confidence: 99%

Synthesis and characterization of novel tetrazole derivatives and evaluation of their anti-candidal activity

Tawfeeq¹,

Muslim²,

Abid³

et al. 2019

actapharm

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This research includes synthesis of new heterocycles containing disubstituted Tetrazole derivatives. Imine compounds were synthesized by reaction of primary aromatic amines with various substituted benzaldehydes in the presence of glacial acetic acid as catalyst in absolute ethanol to obtain new imine compounds O 1-O 5. The novel five-membered heterocycles as Tetrazole derivatives O 6-O 10 were obtained from treatment of each new imine compounds with sodium azide compound. Newly synthesized compounds were identified via spectral methods (FT-IR, 1 H-NMR and 13 C-NMR) spectra and some physical properties. O 6 is the best derivative that has significantly (p<0.01) recorded a stronger influence to inhibit the growth of Candida guilliermondii at an average of the zone of inhibition 14.0 mm. While, O 9 derivative recorded the lowest zone of inhibition 7.3 mm toward the same clinical fungal pathogen. The present work may be helpful in designing more potential antibacterial and antifungal agents for therapeutic use in the future.

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Section: Scheme 3 Structure Of Tetrazole Ringmentioning

confidence: 99%

Synthesis and characterization of novel tetrazole derivatives and evaluation of their anti-candidal activity

Tawfeeq¹,

Muslim²,

Abid³

et al. 2019

actapharm

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“…四唑吲哚类衍生物 57 是一种具有新型结构的抗菌活性化合物, 对革兰阳性菌枯草芽孢杆菌、乳链球菌和革兰阴性菌大肠杆菌、铜绿假单胞菌具有较强的抑菌能力, 与参考药物环丙沙星(Ciprofloxacin)相当. 此外, 该化合物对青霉菌和白色念珠菌也有很高的抑制活性, MIC 值分别为 0.14 和 0.1 mg/mL, 与参照药物夫西地酸 (Fusidic Acid)相近 [75] . [76] .…”

Section: Scheme 10unclassified

Recent Advances in the Synthesis and Application of Tetrazoles

Cui¹,

Damu²,

Guri³

et al. 2013

Chin. J. Org. Chem.

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Tetrazole is an important five-membered aromatic heterocycle with poly-nitrogen electron-rich planar structural feature. This unique structure endows tetrazole derivatives as drugs, explosives, functional materials etc. to exhibit wide potential applications in medicinal, agrochemical, material science and so on. Relevant researches have been becoming active and some important achievements have been made. Based our work on azoles and referring to other literature in recent 5 years, this review systematically summarized the recent advances in the synthesis of tetrazole compounds and their application researches as medicinal drugs, agrochemicals and materials.

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“…1,2,4‐triazole, for example, has been found to inhibit the growth of various cancers including lung, colon, renal, ovarian, leukemia prostate, and breast . Tetrazole and its derivatives, on the other hand, exhibit a wide variety of biological properties including antibacterial, antimicrobial, anti‐inflammatory, antifungal, antiviral, antinociceptive, analgesic, cyclo‐oxygenase inhibition, and anticancer activities . Tetrazole derivatives exhibited anticancer activity against Hep G2, A 549, DU 145, and MCF‐7 cell lines …”

Section: Introductionmentioning

confidence: 99%

Synthesis, characterization, and anticancer activity of some azole‐heterocyclic complexes with gold(III), palladium(II), nickel(II), and copper(II) metal ions

Abdnoor

Alabdali

2019

J Chinese Chemical Soc

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Four new complexes of Au(III), Pd(II), Ni(II), and Cu(II) ions were synthesized, derived from a novel heterocyclic ligand (L) that has both triazole and tetrazole rings. The ligand synthesis was through successive steps to achieve both heterocyclic rings. The synthesized compounds were characterized using conventional techniques like infrared, ultra violet—visible and proton/carbon nuclear magnetic resonance spectroscopy, metal and thermal analyses, and molar conductivity. All complexes were suggested to have square planar geometry, gold, nickel, and palladium complexes were salts while copper neutral complexes have the chemical formulas; [AuL2]Cl.2H2O, [PdL2]Cl2.2H2O, [NiL2]Cl2.2H2O, and [CuL2]. The cytotoxic effect was studied on breast cancer cell line (MCF‐7 cell line) at different concentrations by using the 3‐(4,5‐dimethylthiazol‐2‐yl)‐2,5‐diphenyltetrazolium bromide assay method, for the ligand (L) and complexes. The results showed that gold(III) and nickel(II) complexes have the highest cytotoxicity among all compounds against cancer cell lines.

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Synthesis and antimicrobial activity of new 1-[(tetrazol-5-yl)methyl] indole derivatives, their 1,2,4-triazole thioglycosides and acyclic analogs

Cited by 36 publications

References 38 publications

Synthesis and characterization of novel tetrazole derivatives and evaluation of their anti-candidal activity

Synthesis and characterization of novel tetrazole derivatives and evaluation of their anti-candidal activity

Recent Advances in the Synthesis and Application of Tetrazoles

Synthesis, characterization, and anticancer activity of some azole‐heterocyclic complexes with gold(III), palladium(II), nickel(II), and copper(II) metal ions

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