Synthesis and application of molecularly imprinted silica for the selective extraction of some polar organophosphorus pesticides from almond oil

Acetylcholinesterase electrochemical biosensors with graphene-transition metal carbides nanocomposites modified for detection of organophosphate pesticides

“…However, humans and livestock were posed life-threatening risks by OPs because OPs would inhibit the catalytic activity of acetylcholinesterase (AChE), causing acetylcholine (ATCl) to accumulate in the body without hydrolysis in time, causing damage to the nervous system. In view of these, it is necessary to detect the residual of OPs in food [1][2][3][4][5].…”

A Vortex-Assisted Dispersive Liquid-Liquid Microextraction Followed by UPLC-MS/MS for Simultaneous Determination of Pesticides and Aflatoxins in Herbal Tea

“…Many studies have reported methods for the detection of trace pesticides, which some pesticides have endocrine activity (EDCs) [21] in Chinese herbal medicines: liquid chromatography (LC) and gas chromatography (GC) [22,23], gas chromatography-mass spectrometry (GC-MS) [24] and liquid chromatography-mass spectrometry (tandem) mass spectrometry (HPLC-MS or HPLC-MS/MS) [25]. The methods for detecting mycotoxins such as aflatoxins in traditional Chinese medicine have enzyme-linked immunosorbent assay (ELISA) [26], HPLC [27] and LC-MS/MS [28]. At the same time, pre-treatment procedure such as extraction and concentration are crucial to improving sensitivity and selectivity of the analytical methods owing to the presence of trace amounts of OPPs and aflatoxins and the complexity of real samples.…”

Sample Preparation Using Molecularly Imprinted Polymers

“…40 Boronic acid was also used for its ability to form a reversible covalent complex with cis-diol compounds such as luteolin, 48,49 vitamin B12, 50 sialic acid, 51 or for the specific trapping of glycans of glycoproteins as discussed in more detail below. Many works reported the screening of different synthesis conditions by preparing MIPs using different types of monomers, cross-linkers, template/monomer or monomer/cross-linker ratios, natures of the porogen, 28,30,39,43,[52][53][54][55][56][57][58][59][60][61][62][63][64][65] and even the pH when boronic acid is involved. 50,66 The evaluation of the resulting MIPs consists mainly in comparing the binding capacity of the MIP for the target analyte with the one obtained with the corresponding non-imprinted polymer (NIP) synthesized with the same conditions as the MIP but in the absence of the template molecule.…”

“…The reproducibility of the synthesis was only recently reported, when comparing results from different batches for a MIP prepared by combining reversible addition-fragmentation chain transfer (RAFT) with reflux precipitation polymerization (RPP) 123 and for a MIP monolith synthesized in situ in a 100 µm capillary. 135 MIP-SPE methods were also evaluated by comparing the extraction recoveries obtained using the MIP and other commercially available SPE sorbents 30,39,60,92,131 or obtained with methods such as QuEChERS for food samples. 137 The comparison with conventional SPE sorbents was also carried out to demonstrate the selectivity brought by the MIPs.…”

“…They also allow to limit ion suppression effect in MS. 83 It was also recently reported that the potential remaining matrix effects were reduced with MIPs in comparison with conventional sorbents. 30,82,93,123 The clean extracts obtained by MIP-SPE are usually analyzed by chromatographic methods (mainly LC or gas chromatography -GC-) associated to various types of detectors. Owing to the high clean-up effect brought by the MIP, these methods were sometimes replaced directly by ion mobility spectrometry (IMS) to shorten the analysis duration.…”