Synthesis and Application of H ₂ O ₂ in Flow Reactors

Continuous Flow Synthesis of 16-Dehydropregnenolone Acetate, a Key Synthon for Natural Steroids and Drugs

“…The necessity of removing drawbacks for the oxidative cleavage of pseudodiosgenin-3,26-diacetate ( 3 ) to form diosone ( 4 ) (Scheme , step b) prompted us to evaluate different protocols starting from a preliminary batch screen. In the past, we and others found the use of H 2 O 2 to be beneficial for eco-friendly flow oxidations . In line with these findings, we tested the efficacy of H 2 O 2 as a co-oxidant in the presence of different metal oxides employed as oxidants in substoichiometric amounts (Table ).…”

Continuous flow technology-a tool for safer oxidation chemistry

“…There are many reports concerning the direct synthesis of H 2 O 2 and its utilization in the oxidation of various substrates in continuous flow. 89–93 Besides direct utilization as an oxidant, H 2 O 2 has also been used as a reagent to form higher oxidatively active compounds as described previously. 36,37 In order to apply H 2 O 2 to a variety of transformations, it is often used in combination with additional homogeneous and heterogeneous organocatalysts, acid catalysts, enzymes, metal catalysts, acid metal oxides, polyoxometalates and the sulfonic resin Amberlyst 15.…”

Recent Advances in the Direct Synthesis of Hydrogen Peroxide Using Chemical Catalysis—A Review

“…The microreactors are constructed from silicon, quartz, glass, metals, polymers, and ceramics, to name a few [70]. The work of Shang and Hessel describes the operational-and reaction-based benefits of using microreactors for the direct synthesis of H 2 O 2 in their work [71]. One drawback of using a microreactor for the direct synthesis of H 2 O 2 is the incorporation of the metal catalyst within the capillaries of such a reactor [72].…”