Synthesis and applications of 2-aminopyrimidine derivatives as key intermediates in chemical synthesis of biomolecules

Synthesis, Characterization and DFT Studies of 4-(2,4-Difluorobiphenyl-4-Yl)-6-Phenylpyrimidin-2-Amine

“…The key intermediate (3) was prepared by Claisen-Schmidt condensation method as previously reported [14]. The structure of the compound was established by various spectroscopic techniques like IR, 1 H and 13 C NMR and mass spectrometry.…”

“…Pyrimidine and their derivatives are a type of N-containing heterocyclic scaffolds which comprise of life supporting substances, such as vitamins, coenzymes and uric acid, as well as in many synthetic drugs [1,2].The most important components of living cells like DNA and RNA contain aminopyrimidine ring as a part of its structure [3]. In addition, they possess a wide range of biological effectiveness such as antimicrobial [4], calcium channel blockers [5], antitubercular, anticancer [6], antibacterial [7] and anti-inflammatory [8] activities.…”

Insights into the N,N-diacylation reaction of 2-aminopyrimidines and deactivated anilines: an alternative N-monoacylation reaction

“…19 Finally, 2-N-pyrimidinyl acrylamide has been prepared under forcing conditions (NaH/THF) from acryloyl chloride in modest yield. 20 Acetylation of 2-amino-phenylpyrimidines with acetic anhydride has given both the monoand di-acetylated products, [21][22][23][24][25] which were easily converted into N-monoacylated by treatment in basic medium.…”

“…Previous reports related to this type of transformations have appeared in the literature, but they have been only briefly investigated. 6,[11][12][13][14][15][16][17][18][19][20][21][22][23][24][25] Activation methods have found the reagents to be resistant to amide formation of 2-aminopyrimidines with low or moderate yields. [11][12][13][14] By the addition of the appropriate benzoyl chloride to 2-amino-4-(3-pyridinyl)pyrimidine in refluxing pyridine, 6 a group of N-mono-and N,N-dibenzoyl derivatives has been prepared in low yield.…”

An Efficient Synthesis and In Vitro Antimicrobial Screening of 2-Cyanoimino -4-aryl-6-(1,1'-biphenyl-4-yl)-3,4-dihydro-1H-Pyrimidines

“…They are exhibiting distinguished biological activities based on the functionalities present in their structures like Antimicrobial 2 , Antiplateletal 3 , Anti-plasmodial 4 etc. Aminopyrimidines are an important class of pyrimidine derivatives present in a number of naturally occurring compounds and are biologically active especially in DNA and RNA 5 . The properly substituted 2-aminopyrimidine derivatives have extensive applications in the medicinal field eg.…”