Synthesis and Bioactivities of Novel Piperonylic Acid Derivatives Containing a Sulfonic Acid Ester Moiety

Abstract

The crop loss caused by bacteria has increased year by year due to the lack of effective control agents. In order to develop efficient, broad-spectrum, and structurally simple agricultural bactericide, the structure of piperonylic acid was modified and a series of novel piperonylic acid derivatives containing a sulfonic acid ester moiety was synthesized. Bioassay results indicated the compounds exhibited significantly antibacterial activities. Among them, compound 41 exhibited excellent antibacterial activities against Pseudomonas syringae pv. Actinidiae (Psa), with inhibitory value 99 and 85% at 100 μg/ml and 50 μg/ml, respectively, which was higher than that of thiodiazole-copper (84 and 77%) and bismerthiazol (96 and 78%). In addition, some compounds also showed moderate insecticidal activity against Spodoptera frugiperda. The abovementioned results confirm the broadening of the application of piperonylic acid, with reliable support for the development of novel agrochemical bactericide.

Characterization and Investigation of Novel Benzodioxol Derivatives as Antidiabetic Agents: An In Vitro and In Vivo Study in an Animal Model

“…Moreover, it provided insight into the 3D structure of the compounds. The 3D structure of these compounds was unknown until now to best of our knowledge, and the 3D structures of only two compounds of similar compositions were found in the Cambridge Structural Database (2-[(2H-1,3-benzodioxole-5carbonyl)amino]phenyl 4-fluorobenzene-1-sulfonate [44] and N-(2-Carbamoylphenyl)-6nitroso-1,3-benzodioxole-5-carboxamide [45]. The structural overlay of compounds IIc and IIe for the atoms C8-N1-C9 shows that the conformation of both compounds is the same, as shown in Figure 3.…”