Synthesis and biological activities of new furo[3,4-b]carbazoles: Potential topoisomerase II inhibitors

Palladium‐Catalyzed Sonogashira Reaction for the Synthesis of Arylalkynecarboxylic Acids from Aryl Bromides at Low Temperature

“…3‐(3,4,5‐Trimethoxyphenyl)propiolic Acid (3k): 19 1‐Bromo‐3,4,5‐trimethoxybenzene (5.0 mmol, 1.24 g) gave 3k (873.5 mg, 74 %). 1 H NMR (300 MHz, [D 6 ]acetone): δ = 6.93 (s, 2 H), 3.88 (s, 6 H), 3.78 (s, 3 H) ppm.…”

Microwave-Induced Synthesis of Heterocycles of Medicinal Interests

“…Tripathy and coworkers reported [53] a single-step four-component microwave-assisted synthesis of 1,4,5-trisubstituted imidazoles (Scheme 15). The same authors also reported [54] one-pot four-component synthesis of tetra-substituted imidazoles (35) under microwave-assisted condensation reaction. One molecule of ammonia reacts with one of the carbonyl groups of benzil to form imine.…”

Facile Synthesis of Substituted Furo- and Pyrano-Carbazoles

“…for C 14 H 7 NO 3 : C,70.88;H,2.95;N,5.90%. Found: C,70.94;H,2.98;N,5,6,2,phenanthridin-8-ones (6) and 3,4,5,carbazol-2(13H)-ones (7) General procedure. An appropriate mixture of the respective 1-hydroxycarbazoles (1, 1 mmol) and ethyl 2-oxocyclohexan-2-carboxylate (1 mmol) is treated 2974 K. PRABAKARAN AND K. J. R. PRASAD with fused ZnCl 2 =POCl 3 (1.5 g=6 mL) at 80 C for 6 h. The reaction was monitored by TLC.…”

“…[1][2][3][4][5] Naturally occurring 1-oxygenated carbazoles have attracted great interest because of their diverse and significant biological activity. [6] These alkaloids are mainly extracted from species of the genera Murraya and Clausena, and in the case of 2-and 3-substituted families, their biogenesis has been established.…”