Synthesis and biological activities of diflunisal hydrazide–hydrazones

Synthesis of novel diflunisal hydrazide–hydrazones as anti-hepatitis C virus agents and hepatocellular carcinoma inhibitors

“…2 0 ,4 0 -Difluoro-4-hydroxybiphenyl-3-carboxylic acid hydrazide [2] was prepared by heating hydrazine-hydrate and [1] in methanol [10]. After condensing hydrazide with substituted aldehydes in ethanol, novel 2 0 ,4'-difluoro-4-hydroxy-N'-(arylmethylidene) biphenyl-3-carbo hydrazide [3a-t] were obtained.…”

Comparative Studies of New Complexes Synthesized by Chemical and Tribochemical Reactions Derived from Malonic Acid Dihydrazide (L; MAD) with Cu<sup>2+</sup> and Co<sup>2+</sup> Salts

“…Earlier work illustrated that some drugs show increased activity when administered as metal chelates rather in the form of original organic compounds [7] [8].…”

Crystal Structures and Antimicrobial Activities of N'-[2,5-Dihydroxybenzylidene]-3,4,5-Trimethoxybenzohydrazide, N'-[2,4-Dichlorobenzylidene]-3,4,5-Trimethoxybenzohydrazide, and 2,4-Dichloro-N'-(2-Hydroxy-3-Methoxy-5-Nitrobenzylidene)benzohydrazide Ethanol Solvate

“…[1][2][3] The chemistry of these compounds has been intensively investigated in recent years. The reasons are manifold: the versatile biological activities, such as antibacterial and antitubercular, [4][5][6] the coordination abilities to most metal ions, 7,8 and promising properties for analytical applications. 9,10 As is well known that properties of any material are based on their structures, so, in recent years, the crystal structures of benzohydrazone compounds have attracted much attention.…”