2009
DOI: 10.3390/molecules14072621
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Synthesis and Biological Activity of Some New 1,3,4-Thiadiazole and 1,2,4-Triazole Compounds Containing a Phenylalanine Moiety

Abstract: New 1,3,4-thiadiazole, 6, 7 and 1,2,4-triazole derivatives, 8, 9 containing a phenylalanine moiety have been synthesized by intramolecular cyclization of 1,4-disubstituted thiosemicarbazides, 4, 5, in acid and alkaline media, respectively; the thiosemicarbazides were obtained by reaction of hydrazide 3 with appropriate aromatic isothiocyanates. The toxicity of the synthesized compounds was evaluated and the anti-inflammatory study of the triazole compound 9 established an appreciable anti-inflammatory activity… Show more

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Cited by 73 publications
(46 citation statements)
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“…their anti-inflammatory activity. The anti-inflammatory screening of the triazole compounds established that the compounds possess activity comparable to other standard nonsteroidal anti-inflammatory agents [48].…”
Section: Analgesic and Anti-inflammatory Activitymentioning
confidence: 99%
See 1 more Smart Citation
“…their anti-inflammatory activity. The anti-inflammatory screening of the triazole compounds established that the compounds possess activity comparable to other standard nonsteroidal anti-inflammatory agents [48].…”
Section: Analgesic and Anti-inflammatory Activitymentioning
confidence: 99%
“…A β-lactamase inhibitor, tazobactam (48) has been synthesised successfully by Bennett et al utilising click chemistry. This drug is marketed in combination with the broad spectrum antibiotic piperacillin and has turned out to be a potent β-lactamase inhibitor with higher potency than clavulanic acid and sulbactam.…”
Section: Click Chemistry Of Triazole: New Horizonsmentioning
confidence: 99%
“…1,2,4-Triazoles and their derivatives possess a wide range of biological activities, including analgesic [1], antibacterial [2], fungicidal [3], antin ammatory [4], antiviral [5] and anticancer [6] properties. The title compound was synthesized as potential antibacterial agent [7].…”
Section: Discussionmentioning
confidence: 99%
“…The 1,2,4-triazole derivatives were allied with various pharmacological activities viz. antiseptic, analgesic, anti-convulsant [26][27][28][29][30][31][32][33][34][35][36][37], antibiotic [26], antiallergic [26], anti-inflammatory [26][27][28][29][30][31][32][33][34][35]38], diuretic [26,30,33], fungicidal [28][29][35][36][37][38], insecticidal [28,35,38], herbicidal [28,35,38], antibacterial [28][29][30][31][36][37], antiviral [27][28][29][30]…”
Section: Introductionmentioning
confidence: 99%