Synthesis and biological activity of new cycloalkylthiophene-Schiff bases and their Cr(III) and Zn(II) complexes

Abstract

A series of some novel Ethyl 2-((1-hydroxynaphthalen-2-yl)methyleneamino)-5,6-dihydro-4H-cyclopenta[b]thiopehene-3-carboxylate, Ethyl 2-((1-hydroxynaphthalen-2-yl)methyleneamino)-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxylate, Ethyl 2-((1-hydroxynaphtalen-2-yl)methyleneamino)-5,6,7,8-tetrahydro-4H-cyclohepta [b]thiophene-3-carboxylate and their Cr(III) and Zn(II) complexes have been synthesized. All of these substances have been examined for antibacterial activity against pathogenic strains Listeria monocytogenes 4b (ATCC-19115), Staphylococcus aureus (ATCC25923), Proteus OX2 Wrah (ETS.40-A-4), Escherichia coli (ATCC-1280), Salmonella typhi H (NCTC-901.8394), Pseudomonas putida sp., Brucella abortus (A.99, UK-1995) RSKK-03026. Sh. boydii type 11 (Pasteur51.6), Sh. boydii type 16 (cHe 67.11), Sh. boydii type 6 (RSKK-96043), and antifungal activity against Candida albicans (Y-1200-NIH, Tokyo). Some of the compounds exhibited activity comparable to ampicillin ofloxacin, nystatin, kanamycin, sulphamethoxazol, amoxycillin, and chloroamphenicol. Most of the studied compounds were found effective against bacteria studied and yeast.

Crystal structure of 2-chloro-N'-(2-hydroxy-3,5- diiodobenzylidene)benzohydrazide, C14H9ClI2N2O2

“…Schiff base compounds are aclass of important materials used as pharmaceutical and medicinal fields [1][2][3]. Schiff bases have also been used as versatile ligands in coordination chemistry [4][5][6].…”

Crystal structure of 3-chloro-N'-(2-hydroxy-3,5-diiodobenzylidene)- benzohydrazide methanol solvate, C14H9ClI2N2O2 · CH3OH

“…In recent years, Schiff base compounds have been received considerable attention has for their pharmaceutical and medicinal applications [1][2][3], coordination chemistry [4][5][6], and structural chemistry [7][8][9][10].…”

Crystal structure of 2-chloro-N'-(2-methoxybenzylidene)benzohydrazide, C15H13ClN2O2

“…Schiff bases derived from the condensation reaction of substituted aldehydes with benzohydrazides are ak ind of important compounds in biological [1][2][3] and coordination chemistry [4][5][6].…”