Synthesis and biological activity of 5‑bromo‑2-chloropyrimidin-4-amine derivatives

Ranganatha, V. Lakshmi; Prashanth, T.; Patil, H.B.; Bhadregowda, D. G.; Mallikarjunaswamy, C.

doi:10.1016/j.cdc.2017.11.002

Cited by 1 publication

(1 citation statement)

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“…Substituted-3-phenylamide coumarins (6a-l) were primarily tested for in vitro antibacterial activity against Gram-positive bacterial strains (Streptococcus pyrogenes, Staphylococcus aureus, and Bacillus subtilis) and Gram-negative bacterial strains (Salmonella typhimurium , Klebsiella pneumonia, and Escherichia coli) employing the agar diffusion assay 33,34 . Further, ampicillin the antibiotic drug, was used as a positive control.…”

Section: Biologymentioning

confidence: 99%

Synthesis and Characterization of Coumarin Analogs: Evaluation of Antimicrobial and Antioxidant Activities

Prashanth¹,

Begum²,

Khanum³

et al. 2018

Int. Res. J. Pharm.

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Coumarins and their analogs were found to be better antitumoral agents and still active against human retroviral invading system. This property could be ameliorated by coupling of few active groups to the parental molecule for enhancing its frequency of biofunctional diversity and multi spectrum characteristic, such an endeavor was done by 2-Oxo-2H-chromene-3-carboxylic acid phenylamide analogs. The structure were well characterized. Further the antimicrobial activity was examined by disc diffusion method and based on the minimum inhibitory concentration (MIC) values obtained the molecules were approximately 70% as active as the positive control especially halogenated compounds showed promising result. Even their free radical scavenging activity was considerably as good as 20% to that of ascorbic acid. Present research on coumarin analogs necessitate novel ideas in synthetic chemistry therein concerning the development of innovative synthetic strategies that could help in drug design.

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Section: Biologymentioning

confidence: 99%