Synthesis and biological activity of pyrrolo[1,2,3-de]-quinoxaline derivatives

1-(Phenylsulfonyl)-2-[1-(phenylsulfonyl)-2-(3,4,5-trimethoxyphenyl)ethyl]indole

“…The indole ring system is present in a number of natural products, many of which are found to possess psychotropic (Grinev, Trofimkin, Lomanova, Andreeva & Mashkovskii, 1978), antidepressant (Grinev et al, 1984) and hypertensive (Merk, 1971) properties. They also exhibit antirnicrobial (EI-Sayed, Bamhart, Ammon & Wassel, 1986) and anti-inflammatory (Rodriguez, Temprano, Esteban-Calderon, Martinez-Ripoll & GarciaBlanco, 1985) activity.…”

3-[α-(4-Methoxyphenyl)-β-phenylvinyl]-2-methyl-1-phenylsulfonyl-1H-indole

“…Indole-3-acetic acid is a naturally occurring plant growth hormone that controls a number of plant-growth activities (Fargasova, 1994). Many indole-containing natural products are found to exhibit psychotropic (Grinev et al, 1978) and hypertensive (Merk, 1971) properties. A large number of biologically active compounds, mostly those affecting the central nervous system (Zhang & Liebeskind, 1996), contain indolines and their oxidized counterparts as important pharmacophores.…”

Diethyl {3-[β-(2,4-dichlorophenyl)vinyl]-N-(phenylsulfonyl)indol-2-ylmethyl}phosphonate and diethyl {3-[β-(4-bromophenyl)vinyl]-N-(phenylsulfonyl)indol-2-ylmethyl}phosphonate

“…Organophosphorus compounds are also reported as effective antitumour compounds. The indole ring system is present in a number of natural products, many of which are found to possess antibacterial (Okabe & Adachi, 1998), antitumour (Schollmeyer et al, 1995), antidepressant (Papenstasion & Newmeyer, 1972), psychotropic (Grinev et al, 1978), hypertensive (Merk, 1971), antimicrobial (El-Sayed et al, 1986;Gadaginamath & Patil, 1999) or anti-in¯ammatory activities (Rodriguez et al, 1985;Polletto et al, 1974). Indoles also intercalate with DNA (Sivaraman et al, 1996), and this intercalation between the base pairs in DNA has been implicated for their medicinal properties.…”