Synthesis and Biological Activity of Novel (E)-N’-(Substituted)-3,4,5-Trimethoxybenzohydrazide Analogs

Rambabu, Namala; Ram, Babu; Dubey, P. K.; Bhavani, Vasudha; Bhavani, B.S.

doi:10.13005/ojc/330126

Cited by 6 publications

(2 citation statements)

References 16 publications

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“…Ampicillin was used as the reference medication at a concentration of 200 μg/mL, and DMSO (1 μL) was used as a blank (solvent). After 24 h, the zones of inhibition were calculated [23][24].…”

Section: In Vitro Antimicrobial Activitymentioning

confidence: 99%

Hexahydro-1,2,3-triazine Derivatives: Synthesis, Antimicrobial Evaluation, Antibiofilm Activity and Study of Molecular Docking Against Glucosamine-6-Phosphate

Ayrim,

Hafedh,

Kadhim

et al. 2024

Indones. J. Chem.

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The N,N',N''-trisubstituted hexahydro-1,3,5-triazine derivatives (3a–g) had been created and identified through infrared, nuclear magnetic resonance, and mass spectrometry according to their symmetric basic structure. Three molecules of diverse aromatic amines and three molecules of formaldehyde were assembled in a "1+1+1+1+1+1" condensation reaction to produce hexahydrotriazines. Two Gram-positive (Staphylococcus aureus, Staphylococcus epidermidis) and two Gram-negative (Klebsiella pneumonia, Pseudomonas aeruginosa) bacteria were used to evaluate the antimicrobial activity of the produced compounds. The anti-biofilm activity of 3g against S. aureus was also examined. In this investigation, glucosamine-6-phosphate synthase was employed to investigate the binding affinity of 3g within the enzyme's binding site. The results demonstrated that most of the synthesized hexahydro-1,3,5-triazine compounds have mild antimicrobial effects in comparison with the commonly used drug ampicillin, whereas the compounds 3g are potentially anti-biofilm agents. Molecular docking with the Autodock 4.2 tool was applied to study the binding affinity. It was found to hit (3g) in the active center of glucosamine-6-phosphate synthase as the target enzyme for antimicrobial agents. In silico studies reveal that the discovered hit is a promising glucosamine-6-phosphate inhibitor, as well as that the docking data matched up to the in vitro assay.

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Section: In Vitro Antimicrobial Activitymentioning

confidence: 99%

Hexahydro-1,2,3-triazine Derivatives: Synthesis, Antimicrobial Evaluation, Antibiofilm Activity and Study of Molecular Docking Against Glucosamine-6-Phosphate

Ayrim,

Hafedh,

Kadhim

et al. 2024

Indones. J. Chem.

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“…The wells were filled with the solutions of the test compounds (1000 µg/ml in DMSO), ampicillin (1000 µg/ml) was used as a standard drug, and dimethyl sulfoxide (1µl, DMSO) was used as blank (solvent). The zones of inhibition were then measured after incubation at 37 ºC for 24 hours [25,26].…”

Section: 6: In Vitro Antimicrobial Activity ) …………………………Nov 2022mentioning

confidence: 99%

Synthesis, Biological Activity, and Molecular Docking Studied of New Substituted Hydrazones

Nabel B. Ayrim,

Asim A. Balakit,

Souad J. Lafta

2023

J. K. Chem. Sci.

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Series of new hydrazones derived from different carboxylic acid hydrazides and aromatic aldehydes (7-10, 20-25) have been synthesized and characterized by spectral techniques (FT-IR, 1H NMR, 13C NMR, and Mass spectrometry). The target compounds are designed to have the different substituents at the para position for both parts of the structures (hydrazide and aldehyde parts. The synthesized compounds have been evaluated as antimicrobial agents by studying their biological activity against two bacteria strains Staphylococcus aureus and Staphylococcus epidermidis (as gram-positive bacteria), Escherichia coli and Klebsiella sp (as gram-negative bacteria), the antifungal activity was studied against Candida albicans fungi. The obtained results showed a moderate antimicrobial activity for the test compounds when compared with ampicillin. The synthesized compounds were also subjected to molecular docking studies which were carried out against the bacteria strain Staphylococcus aureus DHFR.

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Coumarin-chalcone hybrids targeting insulin receptor: Design, synthesis, anti-diabetic activity, and molecular docking

Konidala

Kotra

Danduga

et al. 2020

Bioorganic Chemistry

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Synthesis and Biological Activity of Novel (E)-N’-(Substituted)-3,4,5-Trimethoxybenzohydrazide Analogs

Cited by 6 publications

References 16 publications

Hexahydro-1,2,3-triazine Derivatives: Synthesis, Antimicrobial Evaluation, Antibiofilm Activity and Study of Molecular Docking Against Glucosamine-6-Phosphate

Hexahydro-1,2,3-triazine Derivatives: Synthesis, Antimicrobial Evaluation, Antibiofilm Activity and Study of Molecular Docking Against Glucosamine-6-Phosphate

Synthesis, Biological Activity, and Molecular Docking Studied of New Substituted Hydrazones

Coumarin-chalcone hybrids targeting insulin receptor: Design, synthesis, anti-diabetic activity, and molecular docking

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