Synthesis and biological activity of C-terminal fragments of vasopressin

Golubovich, V. P.; Martinovich, V. P.; Usenko, A.B.; Slobodchikova, L. K.; Титов, С. А.; Ашмарин, И. П.

doi:10.1007/bf00763373

Cited by 2 publications

(1 citation statement)

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“…Doses were selected on the basis of results obtained in our laboratory using AVP6. 9 fragments [3]. Control animals received the same volume of distilled water (20 ~tl).…”

Section: Methodsmentioning

confidence: 99%

Improvements in the selective perception and training of rats using an original analog of the C-terminal fragment of vasopressin

Ponomareva

Voskresenskaya

Каменский

et al. 2000

Neurosci Behav Physiol

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This report presents studies on the effects of intranasal administration of five doses (0.001, 0.01, 0.1, 1, and 10 microg/kg) of a new analog of arginine-vasopressin fragment AVP(6-9), i.e., D-MPRG, on the learning ability of rats with positive and negative reinforcement. All doses of the peptide improved learning. The most effective dose was 0.01 microg/kg, at which the peptide accelerated the acquisition of a conditioned active avoidance reflex both when given 1 h before and when given immediately after training sessions. The peptide had greater effects when animals were trained with negative reinforcement. Analysis of the results suggests that the action of D-MPRG is mainly on perception processes, i.e., extraction of the conditioned stimulus from the environmental surroundings and evaluation and enhancement of its biological significance. In addition, this peptide prevented extinction of the acquired habit and improved the processes of consolidation, though this effect was weaker than its effect on perception.

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“…Doses were selected on the basis of results obtained in our laboratory using AVP6. 9 fragments [3]. Control animals received the same volume of distilled water (20 ~tl).…”

Section: Methodsmentioning

confidence: 99%