Synthesis and Biological Activity of 1,11-bis(6,7-Methylenedioxy- and 6,7-Dimethoxy-1,2,3,4-Tetrahydroisoquinolin-1-YL)Undecanes

Terent’eva, E. O.; Saidov, A. Sh.; Khashimova, Z. S.; Tseomashko, Natalya Evgenevna; Сасмаков, С. А.; Abdurakhmanov, D.; Виноградова, В. И.; Azimova, Sh. S.

doi:10.1007/s10600-017-1981-8

Cited by 3 publications

(1 citation statement)

References 9 publications

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“…Two bis (THIQ) derivatives of undecane 150 and 151 were evaluated for their antifungal activity against C. albicans. 43 Compound 150 (zone of inhibition ¼ 20 mm) exhibited better antifungal activity than nystatin (zone of inhibition ¼ 15 mm). Zablotskaya and co-workers also evaluated compounds 138-141 for their antifungal property.…”

Section: Anti-fungal Activitymentioning

confidence: 99%

Medicinal chemistry perspectives of 1,2,3,4-tetrahydroisoquinoline analogs – biological activities and SAR studies

et al. 2021

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Section: Anti-fungal Activitymentioning

confidence: 99%

Medicinal chemistry perspectives of 1,2,3,4-tetrahydroisoquinoline analogs – biological activities and SAR studies

et al. 2021

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Synthesis and Study of the Reaction Kinetics of Homoveratrilamine With Brassylic Acid by HPLC

2020

IJESRT

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In this work, amide, isoquinoline were synthesized and the kinetics of the reaction of homoveratrylamine with brassilic acid was studied by HPLC. The conditions of (high-performance liquid) chromatographic separation were revealed, which allow satisfactory separation of the components of the reaction mixture consisting of reagents, intermediates and products of the reactions of condensation and cyclization. By studying the kinetic laws, it was found that the reactions of condensation and cyclization obey the first-order kinetic equation and the activation energy is, respectively, 172.3 kJ / mol for the amide condensation reaction, and 118.8 kJ / mol for the cyclization reaction.

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Cytotoxicity Is the Key Test for In Vitro Toxicity

Ekaterina Olegovna,

Zaynat Sattarovna,

Umida Bakhriddin Kizi

et al. 2024

Cytotoxicity - A Crucial Toxicity Test for in Vitro Experiments [Working Title]

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Currently, a lot of new chemical compounds are registered in the world, some of them are used in various fields of medicine, pharmaceuticals or related fields. In this case, each of the introduced chemical compounds must be assessed toxicologically. In vitro cell models are used to elucidate the mechanisms of differentiation and proliferation, interaction of cells with the environment, adaptation, aging, biological activity, malignant transformation, for the diagnosis and treatment of hereditary diseases, and as test objects when testing new pharmacological substances. The review presents the advantages of using cell models, provides methods for studying the cytotoxic effects of target agents, and discusses the system for controlling the contamination of materials. In addition, the necessity to search for new cytostatics in the context of a steady trend of growth in new cases of cancer and the imperfections of existing anticancer drugs is discussed, and studies of the cytotoxicity of a number of promising tetrahydroisoquinolines, their structural-functional relationship, the type of triggering of cell death and the mechanism of manifestation of cytotoxicity are presented.

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Synthesis and Biological Activity of 1,11-bis(6,7-Methylenedioxy- and 6,7-Dimethoxy-1,2,3,4-Tetrahydroisoquinolin-1-YL)Undecanes

Cited by 3 publications

References 9 publications

Medicinal chemistry perspectives of 1,2,3,4-tetrahydroisoquinoline analogs – biological activities and SAR studies

Medicinal chemistry perspectives of 1,2,3,4-tetrahydroisoquinoline analogs – biological activities and SAR studies

Synthesis and Study of the Reaction Kinetics of Homoveratrilamine With Brassylic Acid by HPLC

Cytotoxicity Is the Key Test for In Vitro Toxicity

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