Synthesis and Biological Activity of 3-Aryl-1-(3-Methyl-5- Styryl-4-Isoxazolyl)-2-Oxo-(1h,3h,5h)-Pyrimidine-4,6-Diones

Rajanarendar, E.; Thirupathaiah, Kammari; Rao, E. Kalyan; Reddy, A. Siva Rami

doi:10.1515/hc.2008.14.5.323

Cited by 2 publications

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“…These results prompted our research on the synthesis of substituted bi-heterocycles, and we concluded that it would be advantageous to create and evaluate compounds that have the isoxazole moiety coupled to the pyrimidine nucleus in order to combat fungus. [10] A versatile soil-borne fungus called Macrophomina phaseolina is widespread over the entire earth, it can result in diseases like seedling blight, charcoal rot, stem rot and root rot. [11] When there is a combination of high soil moisture content and warmth, this fungus can lead to substantial yield losses in crops including soybean, sorghum, and peanuts.…”

Section: Introductionmentioning

confidence: 99%

“…The antimicrobial agent resistance has grown to be a serious and urgent global issue. These results prompted our research on the synthesis of substituted bi‐heterocycles, and we concluded that it would be advantageous to create and evaluate compounds that have the isoxazole moiety coupled to the pyrimidine nucleus in order to combat fungus [10] …”

Section: Introductionmentioning

confidence: 99%

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Novel Isoxazolylpyrimidine Derivatives: Design, Synthesis, Antifungal Activity and In‐Silico Studies

Nagaraja rao,

Poojary,

Mohan Kumar

et al. 2024

Asian J Org Chem

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The advancement of environmentally friendly chemical synthesis in both academic and corporate research has recently taken on enormous relevance. Pesticides are substances, either chemical or biological, that are used to get rid of or lessen the impact of pests. To control the fungi in crops a new set of isoxazolylpyrimidine derivatives were planned, synthesized, and characterized. The compounds indicated were synthesized in high yields, and their structures were determined using elemental analysis, 1H‐NMR, 13C NMR, and LCMS. HPLC was used to assess the purity of the synthesized molecules, and the purity of some compounds were found to be >98% a/a while a couple were found to be >95% a/a. The synthesized compounds were assessed for their antifungal activity. Among these, compounds 5d, 5h, and 5l exhibit substantial antifungal action and considerably suppress the growth of Rhizoctonia solani, Sclerotium rolfsii, and Macrophominaphaseolina. The plausible mechanism of fungal inhibitory activities of rationally designed isoxazolyl pyrimidine derivatives is attributed to the blocking of the oxygen activation of heme Iron in membrane‐bound 14 alpha‐demethylase. The presence of pyrimidine unit in designed materials is a vital factor for inducing antifungal activities, which was further corroborated through the density functional theory (DFT) and molecular docking studies.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%